CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade de São Paulo (2000), master's at Biochemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (2003) and doctorate at Farmacologia from Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo (2006). Has experience in Pharmacology, focusing on Pharmacology, acting on the following subjects: fungos, purificação de enzimas, xilanases, resíduos agroindustriais and hipertensão arterial. (Source: Lattes Curriculum)
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Preeclampsia (PE) is a hypertensive syndrome of pregnancy, characterized byblood pressure ¿140/90 mmHg, often accompanied by proteinuria and end-organ dysfunction.It affects 2-8% of pregnancies worldwide and represents an important cause ofmaternal and perinatal morbidity and mortality. The pathophysiology involves two stages: failure of uterine spiral artery remodeling, leading to placen…
Live-cell image visualization is an effective tool that empowers scientists to study living organisms instantly. Especially when used in conjunction with fluorescence microscopy, this technique enables the observation of cellular components with great sensitivity and precision. By illuminating the dynamics of different compounds and structures in living cells, it is possible to clarify th…
Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death worldwide. Half of patients with PE do not respond to current therapies, and despite this, its pathophysiology is not yet fully understood. It is known that endothelial dysfunction, inflammation and oxidative stress are fundamentally important in this process. Persistent inflammatio…
(Only some records are available in English at this moment)
(1) Background: Preeclampsia (PE) is characterized by great endothelial dysfunction, decreased nitric oxide (NO) bioavailability, and higher levels of arginase activity. In the present study, we investigated the potential modulatory effects of trans-Resveratrol (RSV) on arginase and endothelial dysfunction biomarkers in endothelial cells exposed to plasma from patients with PE and healthy…
Preeclampsia is the main cause of mortality and morbidity among pregnant women in Brazil and in several countries. The pathophysiology of this disease is complex and involves several processes. One of them is related to deficiency of the nitric oxide (NO). A possible cause of this deficiency could be the high expression of the enzyme arginase, which competes for the substrate (L-arginine)…
Telomere length is considered to be a biomarker of biological aging and age-related disease. There are few studies that have evaluated the association between telomere length and diet, and none has evaluated the impact of a vegetarian diet on telomere length and its correlation with cardiovascular biomarkers in apparently healthy subjects. Therefore, our objectives were to evaluate leukoc…
(Only some records are available in English at this moment)
1.289 / 5.000Preeclampsia (PE) is a hypertensive syndrome of pregnancy, characterized by blood pressure ¿140/90 mmHg, frequently accompanied by proteinuria and target organ dysfunction.1 It affects 2-8% of pregnancies worldwide and represents a significant cause of maternal and perinatal morbidity and mortality.1 The pathophysiology involves two stages: failure of remodeling of the uterin…
Pre-eclampsia (PE) is a leading global cause of maternal and perinatal morbidity and mortality. Notably, over 40% of pregnant women do not respond adequately to antihypertensive therapy, experience adverse events, and could benefit from targeted treatments. While the exact pathophysiology of PE remains incompletely understood, placental ischemia plays a pivotal role, and the release of an…
Preeclampsia (PE) is a gestational hypertensive syndrome characterized by blood pressure ¿140/90 mmHg, frequently accompanied by proteinuria and target organ dysfunction.<sup>1</sup> It affects 2-8% of pregnancies globally and represents one of the main causes of maternal and perinatal morbidity and mortality.<sup>1</sup> Its pathophysiology is described in two stages: initially, there is…
(Only some records are available in English at this moment)
It is likely that the Endothelial Dysfunction (ED) found in Hypertensive Disorders of Pregnancy are evoked by the actions of multiple factors and several pathways. Then the discovery and the understanding of these converging pathways that contribute to ED and pooroutcome of pregnancy can addressing potential molecules with are modulated by different drugs. The use of omics tools, such as …
In recent years, the dysregulation of steroid hormones has emerged as a significant endocrinopathy associated with clinical manifestations of Preeclampsia. Progesterone and estrogens play a regulatory role in uterine vessels by reducing resistance in spiral uterine arteries and influencing the production and release of angiogenic factors by the placenta. Conversely, androgens have the opp…
Preeclampsia (PE) is a human gestational disorder, one of Brazil's leading causes of obstetric maternal death. Although its physiopathology hasn't been completely elucidated, PE is related to placental ischemia, once the release of substances resulting from inadequate perfusion in the maternal circulation can lead to systemic endothelial dysfunction. These substances can behave like infla…
(Only some records are available in English at this moment)
Preeclampsia (PE) is a hypertensive pregnancy disorder marked by endothelial dysfunction and impaired angiogenesis, with limited effective treatments currently available. Reduced nitric oxide (NO) bioavailability, driven by placental hypoxia and oxidative stress, is a key factor in PE pathophysiology. Nitrite, an alternative NO source under hypoxic conditions, has demonstrated vasodilator…
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that contributes significantly to maternal and perinatal morbidity and mortality, both globally and in Brazil. The disease is classically described as a two-stage disorder: the first stage involves defective remodeling of uterine spiral arteries, resulting in placental hypoxia and syncytiotrophoblast stress; the second stage …
Preeclampsia (PE) is a complex hypertensive disorder of pregnancy characterized by abnormal placental development, endothelial dysfunction, and systemic inflammation. Emerging evidence suggests that exposure to environmental endocrine-disrupting chemicals (EDCs), such as phthalates, may contribute to the development and severity of PE. Di(2-ethylhexyl) phthalate (DEHP), a widely used plas…
Preeclampsia (PE) is a specific syndrome of human pregnancy and the clinical parameters that define it are well understood. However, given the severity for the mother and fetus and the confirmation of the diagnosis only after the twentieth week of gestation, many studies have evaluated the use of biomarkers, such as the ratio between sFlt-1 (soluble vascular endothelial growth factor rece…