CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's at Ciências Biológicas from Universidade Estadual de Campinas (2003), bachelor's at Ciências Biológicas from Universidade Estadual de Campinas (2005), master's at General Biology from Universidade Estadual de Campinas (2008) and doctorate at General Biology from Universidade Estadual de Campinas (2012). Nowadays she is Assistant Professor Ph.D. at Universidade Estadual Paulista " Julio de Mesquita Filho ". Has experience in the area of #8203;#8203;Morphology, focusing on Anatomy, acting on the following subjects : Duchenne muscular dystrophy , mdx mice , blocking calcium channels and biomarkers. (Source: Lattes Curriculum)
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Introdução: A distrofia muscular de Duchenne (DMD) é uma forma grave de distrofia muscular sem tratamento eficaz, causada por mutações no gene DMD, levando à ausência de distrofina. A DMD resulta em fraqueza muscular, perda de ambulação e morte em idade precoce. Estudos de metabolômica em camundongos mdx, modelo mais utilizado para DMD, revelam mudanças nos metabólitos associados à degene…
Duchenne muscular dystrophy (DMD) is a lethal pediatric disorder with no cure, exhibiting an epidemiological prevalence of approximately 2.8 cases per 100,000 births. DMD progressively compromises skeletal striated muscle function, leading to loss of ambulation and impairment of vital activities. Current treatment with glucocorticoids provides palliative care by delaying symptoms and dise…
Obesity, a global public health issue, is characterized by an excess of body fat caused by nutritional imbalance where food intake exceeds energy expenditure. Excessive adipose tissue secretes pro-inflammatory cytokines, resulting in an inflammatory condition associated with comorbidities. The provision of a high-fat diet serves as a preclinical model for studying obesity, increasing adip…
Duchenne muscular dystrophy (DMD) is a lethal pediatric muscle disease that leads to progressive weakness and wasting of the skeletal and cardiac striated muscles. It is characterized by the absence or low expression of dystrophin, leading to recurrent muscle fiber damage, chronic inflammation, and fibrosis. The mdx mouse is a commonly used model in DMD research due to its similarity in t…
Biomarkers are cellular, structural and biochemical components that can be used as parameters to evaluate the presence and progression of a disease. Duchenne muscular dystrophy (DMD) is a progressive degenerative disease that affects skeletal and cardiac muscles leading the patient to death. In DMD, the absence of the protein dystrophin results in sarcolemmal fragility, deficiency in its …
(Only some records are available in English at this moment)
Duchenne Muscular Dystrophy (DMD) is an X chromosome-linked and the most common hereditary muscular disease in childhood. Mutation in the DMD gene leads to the absence of dystrophin, a subsarcolemmal protein, which is part of dystrophin-glycoproteins complex (DGC). The mdx mice, DMD model, shows the first signs of degeneration around 20 days of age and around 26 months of age shows typica…