CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Biological Sciences from São Paulo State University - UNESP (1987), master's at Cell Biology from Campinas State University - UNICAMP (1990) and ph.d. at Cell and Structural Biology from Campinas State University - UNICAMP (1997). Has experience in Morphology, acting on the following subjects: Cytochemistry, Prostate Biology, extracellular matrix, endocrine disruption, epithelium-stroma interaction, experimental spermatogenesis, Histopathology of genital system. Is board member of the Brasilian Society for Cell Biology - SBBC (2014-2016). (Source: Lattes Curriculum)
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Advances in studies on the developmental origins of health and disease (DOHaD) provide information on the emergence of pathologies throughout life. Diseases associated with DOHaD are related to factors, such as poor nutrition, stress, and chemical agents. Among them, endocrine disruptors (EDCs) show a relevant impact on multiple generations since they are widespread in the environment. Cu…
In our multi-user microscopy and microanalysis center, Transmission Electron Microscopy has been an extremely important tool in the diverse areas of biological, medical and materials science. In general, researchers at our Institute have accumulated experience using this equipment, mainly in collaborations, in Brazil and abroad. Furthermore, many sample evaluation services for companies a…
The mammary glands and female prostate are organs associated with the female reproductive system that undergo hormone-responsive changes. Pathologies associated with these glands are the result of endocrine deregulation via endogenous or exogenous pathways. Endocrine disruptors (ED) are chemical compounds disseminated in the environment that show activity via hormone receptors and interac…
The development of new treatments against diseases related to the mammary gland and prostate depends on the knowledge about the morphology, physiology and pathology of these glands. Gerbils (Meriones unguiculatus) have been widely used in scientific experiments, since they have an affordable maintenance cost, are small, relatively easy to handle and resistant. This project aims to evaluat…
(Only some records are available in English at this moment)
The mammary gland is an organ susceptible to hormonal changes according to the different stages of life and female estrous cycles. Among the hormones that interact to cause these cyclic modifications, estrogens and progesterone act as protagonists in epithelial and stromal alterations. However, women are subject to endocrine disruptors present in the environment and hormonal therapies, su…
Prostate cancer is the most common neoplasia among men in the world. It is a complex pathology, highly sensitive and responsive to the steroid hormones action, just like the normal prostate, which depends on their action for its development and homeostasis. In this scenario, it is notable that disturbances in the hormone levels, through their own receptors (AR, ER± and ER²), lead to pre-m…
Mammary glands are constituted of glandular epithelial cells and myoepithelial cells, and in the stromal region, fibroblasts, and inflammatory cells. Its development and activity are mainly influenced by the endocrine system. The acquisition of the reactive stroma phenotype is observed when there are disturbances in stromal homeostasis, leading to changes in extracellular matrix compositi…
The prostate is a gland commonly associated with the male urogenital system, but recently it has been described in females of several mammals, being a current target of experimental studies. This gland is regulated by steroid hormones and endocrine disruptions can affect its development and morphologic features. Studies regarding the exposure to endocrine disruptors, such as the xenoestro…
The female prostate (Skene's paraurethral gland) is an organ associated with the urogenital system, which is influenced by hormones, such as androgens and estrogens. Several exogenous chemical compounds, i.e. endocrine disruptors, present effects through endocrine pathways that change prostate morpho-physiology. One of these compounds is bisphenol A (BPA), which acts through estrogenic pa…
(Only some records are available in English at this moment)
Mammary gland (MG) biology shows high complexity related to stromal, which requires an intense remodeling of extracellular matrix (ECM) components influenced by ovarian-derived hormones. Parity and hormonal profile are intrinsic changes that affect ECM composition. The stromal microenvironment's role could extend to breast cancer development, where alterations in proteoglycans, glycosamin…
The incidence of cancer has been higher in the last few decades. The challenge of developing new studies amongst prevention and treatment for these diseases has motivated numerous research groups through the world. Even so, the knowledge about etiology is still scarce and treatments already established are known to cause several side effects in patients, especially in the gonads. Women su…
| 2 / 2 | Ongoing grants |
| 21 / 11 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 68 / 47 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 95 / 64 | All research grants and scholarships |
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