CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina Veterinária e Zootecnia (FMVZ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Veterinary Medicine from the School of Veterinary Medicine and Animal Science - Unesp, Botucatu campus (1991), with a Residency in Large Animal Clinic (1992-1993) specializing in Veterinary Neurology. Holds a Master's degree (1997) and a Ph.D. (2002) in Veterinary Clinic from FMVZ-Unesp. Completed postdoctoral studies in Cell Therapy at the Veterinary Institute for Regenerative Cures - University of California, Davis - USA. Leader of a research group at CNPq and academic coordinator of the Interdisciplinary Studies in Cannabis League - NEICANN - Unesp. Associate professor of the Department of Veterinary Clinic and the Graduate Program in Veterinary Medicine (Capes rating 7) at the School of Veterinary Medicine and Animal Science - Unesp, Botucatu campus. Engaged in teaching, research, and extension activities in the areas of Veterinary Clinic, Veterinary Neurology, Cell-based Therapy, Regenerative Medicine, and Cannabis sativa L.. (Source: Lattes Curriculum)
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Cell-based therapy using mesenchymal stem cells (MSCs) shows promise for treating several diseases due to their anti-inflammatory and immunomodulatory properties. To enhance the therapeutic potential of MSCs, in vitro priming strategies have been explored. Cannabidiol (CBD), a non-psychoactive compound derived from cannabis, may influence MSC proliferation, differen-tiation, and immunomod…
Inflammatory injuries of the central nervous system (CNS) are particularly disabling for both human and domestic animals. Multiple Sclerosis (MS) in humans and Meningoencephalomyelitis of Unknown Origin (MUO) in dogs are the most common neuroimmune diseases. The Experimental Autoimmune Encephalomyelitis (EAE) in mice, as animal model for MS, has contributed to the understanding of the pat…
Studies with mesenchymal stem cells (MSCs) are increasing due to their immunomodulatory,anti-inflammatory and tissue regenerative properties. However, there is still no agreementabout the best source of equine MSCs for a bank for allogeneic therapy. The aim of this studywas to evaluate the cell culture and immunophenotypic characteristics and differentiationpotential of equine MSCs from b…
(Only some records are available in English at this moment)
This project aims to isolate, characterize and transplant intrathecally extracellular vesicles (EVs) derived from mesenchymal stem cells in horses. For this, characterization techniques by nanoparticle analysis, flow cytometry and transmission electron microscopy will be used. We hypothesize that it is possible to isolate EVs and transplant them safely, in the future using them as a thera…
Peripheral nervous system (PNS) injuries are common clinical conditions in humans and animals, affecting the quality of life of affected patients. Equines are relevant as a translational model, as peripheral nerve injuries are common in the species, and the nerve size allows for more realistic data on nerve regeneration in humans. Although the PNS has regenerative capacity, mainly due to …
Experimental autoimmune neuritis (EAN) can be induced in a murine animal model, with the aim of providing a source for understanding pathophysiological mechanisms, or even searching for new treatments for immune-mediated inflammatory diseases of the peripheral nervous system. Examples include Guillain-Barré syndrome (GBS) in humans and acute canine polyradiculoneuritis (ACP) in dogs. ACP …
(Only some records are available in English at this moment)
Research in regenerative medicine has advanced with the use of mesenchymal stem cells (MSCs). These cells are characterised by their fibroblast-like morphology, mesenchymal immunophenotype, self-renewal capacity, and differentiation potential into osteogenic, adipogenic, and chondrogenic lineages. MSCs can be isolated from various tissues, such as adipose tissue, and their therapeutic pot…
Cannabidiol (CBD), the main non-psychoactive component of Cannabis sativa, has shown promise due to its therapeutic potential as an alternative to traditional medications in various areas of veterinary medicine, especially in the treatment of inflammation, chronic pain, and neurological disorders in animals. However, there is a significant gap in knowledge regarding its safety and efficac…
The diagnosis of immune-mediated diseases has become increasingly common in Veterinary Medicine, increasing the use of immunomodulatory substances to promote a better quality of life for the animal, given that they have no cure. The drugs most used to treat these diseases are glucocorticoids, which have multiple long-term adverse effects. Because of this, therapeutic alternatives, such …
(Only some records are available in English at this moment)
Over the past decade, stem cell therapy has become a corner stone in translational and regenerative medicine for many diseases. However, brain and spinal cord diseases represent a challenge in stem cell based therapy. Stem cells therapies for CNS injury can be driven either with cell replacement by transplanted stem cells or by stimulation of endogenous CNS stem cells; and by the improvem…
Mesenchymal stem cells (MSCs) are a promising tool for treatment of a variety of injuries and disorders because of their secretion of numerous bioactive molecules leading to tissue regeneration. The central nervous system (CNS) has a limited capacity for regeneration. As such, MSCs are being evaluated as a cell therapy for a number of chronic degenerative and inflammatory neurological con…