CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
I have a Pharmacy Degree (Pharm.B., 2002) and a Masters Degree (M.Sc., 2004) in Pharmaceutical Sciences from Federal University of Pernambuco (Brazil), a Doctoral Degree (Ph.D., 2009) from Federal University of São Paulo (Brazil), and an Habilitation in Pharmacology (2025) from São Paulo State University (Brazil). I was a post-doctoral associate at The Laboratories for Reproductive Biology, University of North Carolina - Chapel Hill (USA) from 2010 to 2012, and a Young Investigator - CNPq Program Science without Borders at the Department of Pharmacology, Federal University of São Paulo from 2012 to 2015. Since 2014, I have been a faculty member at the Department of Biophysics Pharmacology, Institute of Biosciences of Botucatu, São Paulo State University, where I am currently an Associate Professor. I have solid international experience in Pharmacology, focusing in Cellular and Molecular Pharmacology, Experimental Endocrinology, Reproductive Biology, and Andrology, working on the following research fields: 1) Epididymis: characterization of mechanisms involved on the regulation of epididymal gene expression and functions, as well as identification of epididymal protein targets for the development of male contraceptive drugs; 2) Actions of androgen and glucocorticoid hormones in the male reproductive tract; 3) Functions and mechanism of action of antimicrobial genes as members of innate immunity in the male reproductive tract and their role in male fertility; and 4) Characterization of protein-protein interactions in the epididymis and sperm with roles in sperm maturation and motility. (Source: Lattes Curriculum)
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The alarming rate of unintended pregnancies (almost 50%) contributes to the unsustainable world population growth and can have serious health and socioeconomic consequences for women and their families. This scenario underscores the need for novel contraceptives, especially male options, since they are limited to condoms and vasectomy. Druggable proteins with crucial roles in regulating s…
The alarming rate of unintended pregnancies (almost 50%) contributes to the unsustainable world population growth and can have serious health and socioeconomic consequences for women and their families. This scenario underscores the need for novel contraceptives, especially male options, since they are limited to condoms and vasectomy. Druggable proteins with crucial roles in regulating s…
Almost 30% of couples rely on the two currently available options of male contraception: condoms and vasectomy, which have issues regarding effectiveness and reversibility, respectively. Thus, there is an unmet need for new male contraceptive methods, which will contribute to decreasing unintended pregnancy rates and to improve family planning, health and well-being. Protein-protein inter…
Nearly 50% of the pregnancies worldwide are unintended, which causes 80,000 maternal deaths every year due to unsafe abortions. This indicates there is an unmet need for new male contraceptive methods, which would facilitate family planning and promote family health. EPPIN (Epididymal protease inhibitor) is a promising target for male contraception due to its crucial role on reproduction …
Dengue virus (DENV) is one of the flaviviruses with the greatest impact on global public health, with four distinct serotypes and widespread distribution in tropical and subtropical regions. In 2024, Brazil recorded the largest dengue epidemic in its history. The disease can be asymptomatic or induce symptoms ranging from fever, chills, headache, and myalgia to hemorrhagic manifestations …
Upon release from the seminiferous tubules, spermatozoa undergo essential post-testicular maturation in the epididymis to acquire full motility and fertilization capacity. The epididymis, a single, highly coiled, and convoluted tubule, hosts spermatozoa in a luminal compartment surrounded by a pseudostratified epithelium composed of various cell types. The interaction between immune cells…
(Only some records are available in English at this moment)
Unintended pregnancies correspond to 50% of pregnancies worldwide, leading to health, social, and economic problems for women and their families. Expanding access to contraceptive options is a key strategy to reduce the number of unplanned pregnancies and a goal of the UN's 2030 Agenda for Sustainable Development. Almost 30% of couples rely upon male contraceptive methods, which are curre…
Novel male contraceptive strategies will foster the participation of men in family planning and sharing the contraceptive burden with women. The sperm protein EPPIN (epididymal protease inhibitor) is a target for non-hormonal, on-demand male contraceptive drug development. The physiological relevance of EPPIN is driven by its role as a sperm-surface binding site for seminal plasma protein…
In mammals, proteins belonging to the REST (rapidly-evolving seminal vesicle transcribed) family, secreted by the seminal vesicles, are the most abundant components of the seminal plasma. In humans, the major REST protein is semenogelin-1 (SEMG1), which binds EPPIN on the surface of ejaculated spermatozoa, leading to inhibition of sperm motility that lasts until SEMG1 is cleaved by prosta…
(Only some records are available in English at this moment)
The sperm proteome contains exclusively expressed proteins with essential roles in male fertility, which may have therapeutic applications in male contraception. Among the proteins that fit into this profile, we highlight the protein phosphatase 1 gamma 2 (PP1¿2). PP1¿2 is a sperm-specific isoform of a family of phosphatases that act dephosphorylating serine/threonine residues of target p…
After ejaculation, mammalian spermatozoa need to undergo several molecular and biochemistry changes to fertilize the egg. The major protein of the seminal plasma is semenogelin 1 (SEMG1), which plays several roles in the modulation of sperm function, such as motility, hyperactivation and capacitation. SEMG1 modulates sperm function by interacting with EPPIN, a cysteine-rich protein found …
| 2 / 2 | Ongoing grants |
| 3 / 2 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 12 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 24 / 22 | All research grants and scholarships |
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