CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor of Pharmacology, UNESP, Botucatu, Sao Paulo, Department of Biophysics and Pharmacology. Pharmacist (2002), Master (2004), and Ph.D. (2007) in Pharmacology. Postdoctoral Research Fellow at the Department of Pharmacology (USP, 2009) and at Harvard Medical School (2016). Adviser of masters and Ph.D. students, Biomolecular and Pharmacological Sciences (UNESP, Botucatu, Sao Paulo). The main focus is cardiovascular pharmacology. Full member (since 2003) of the Brazilian Society of Pharmacology and Experimental Therapeutics (SBFTE). (Source: Lattes Curriculum)
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Preeclampsia has an unclear pathogenesis. The pathophysiology appears to begin after inappropriate trophoblastic invasion, which results in placental hypoxia and ischemia. The ischemic placenta releases harmful factors in excess, including reactive oxygen species (ERROR), into the blood circulation, resulting in maternal endothelial dysfunction. ROS have been related to the uncoupling of …
It is likely that the Endothelial Dysfunction (ED) found in Hypertensive Disorders of Pregnancy (HDP) are evoked by the actions of multiple factors and several pathways. Then the discovery and the understanding of these converging pathways that contribute to ED and poor outcome of pregnancy can addressing potential molecules with are modulated by different drugs. The use of omics tools, s…
Preeclampsia (PE) is a disease that occurs in pregnancy and is characterized by elevated maternal blood pressure accompanied by endothelial dysfunction. Its pathogenesis is still not well understood; however, placental ischemia and hypoxia has shown importance in pathophysiology. In PE there is an increase in oxidative stress, increases in antiangiogenic factors and decreases in vasodilat…
Hypertensive disorders of pregnancy are characterized by an increase in systemic blood pressure. Preeclampsia is considered the most severe of these disorders and is usually accompanied by proteinuria and other clinical symptoms after the 20th gestational week. Perivascular adipose tissue (PVAT) may participate in the control of vascular tone through the release of vasoactive substances, …
Under gestation period, several cardiovascular adaptations must occur to maintain a healthy pregnancy. Preeclampsia (PE) is a disorder that occurs during pregnancy that is characterized by elevated maternal blood pressure (140x90mmHg) accompanied by proteinuria in 24-hour urine after the 20th week of pregnancy. Its pathogenesis is still unclear; however, the placenta seems to play a key r…
(Only some records are available in English at this moment)
Nitric oxide (NO) is an endogenous mediator essential for maintaining vascular function during pregnancy, playing a key role in systemic vasodilation and regulation of peripheral vascular resistance. In preeclampsia, a specific hypertensive disorder of pregnancy, NO synthesis and bioavailability are impaired, contributing to endothelial dysfunction, increased vasoconstriction, and elevate…
Preeclampsia is a hypertensive disorder of human pregnancy, characterized by hypertension associated with proteinuria or target organ damage. It is one of the main causes of maternal and fetal mortality worldwide, especially in lower-income countries. In Brazil, the data is underestimated, but it is estimated that preeclampsia affects at least 1.5% of pregnancies in the country. Although …
Abstract Preeclampsia (PE) is a gestational hypertensive syndrome that affects approximately 2 to 8% of pregnant women and is one of the leading causes of maternal-fetal morbidity and mortality. The pathophysiology of PE involves abnormal placentation, endothelial dysfunction, and systemic inflammation, but effective pharmacological treatment is still lacking. The objective of this study …
(Only some records are available in English at this moment)
Preeclampsia is a gestational hypertensive syndrome that affects 1.5% of pregnancies in Brazil. It is one of the main causes of maternal-fetal mortality worldwide, especially in low-income countries. Although its etiology is still unknown, its pathophysiology is characterized by oxidative stress and deficient trophoblastic invasion in the spiral arteries, which would give later rise to th…
Preeclamsia is a disease caused by deficient trophoblastic invasion during the placentation period, bringing about malformation of the spiral arteries. As a result, placental hypoxia and ischemia occurs, with liberation of anti-angiogenic factors, pro inflammatory antigens and reactive oxygen species from the placenta that will entail in generalized maternal endothelial dysfunction and, t…
Nitric oxide (NO) is a critical endogenous mediator involved in various physiological aspects of healthy pregnancy, including implantation, placental perfusion, maternal systemic vasodilation, and renal adaptation during pregnancy. NO deficiency during pregnancy has been associated with various hypertensive disorders, such as preeclampsia (PE). S-nitrosylation represents the major route f…
(Only some records are available in English at this moment)
Preeclampsia (PE) is a hypertensive disorder of human pregnancy, characterized by hypertension associated with proteinuria or target organ damage. It is one of the main causes of maternal and fetal mortality worldwide, especially in lower-income countries. Although underestimated, PE affects at least 1.5% of pregnancies in Brazil. Its pathogenesis is not fully understood, however its path…
Hypertensive pregnancy disorders are a worthy cause of maternal and fetal mortality. Among them, preeclampsia/eclampsia is more severe and is characterized by elevations in maternal blood pressure along with end-organ failure which may compromise fetal development. The pathogenesis is still unknown, but there are theories that an impairment occurs in the plasticity of the vessels of the m…
Preeclampsia affects 5-8% of pregnancies and is characterized by increased blood pressure and proteinuria from 20 weeks of gestation. These changes appear to be initially related to placental ischemia, causing insufficient uteroplacental oxygenation followed by increased release of anti-angiogenic factors such as sFlt-1 (soluble fms-like tyrosine kinase-1, which is a soluble VEGF receptor…
| 2 / 2 | Ongoing grants |
| 7 / 6 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 14 / 13 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 31 / 29 | All research grants and scholarships |
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