Jose Carlos Peraçoli

• Abstract

  Hypertensive disorders of pregnancy are one of the main causes of maternal and perinatal mortality worldwide. Pre-eclampsia is a multisystem disease characterized by intense activation of innate immunity components such as the NLRP3 inflammasome complex, which is responsible for the production of high levels of Interleukin-1 (IL-1²) and IL-18 in both placenta and peripheral blood. As a cl…

  Effect of magnesium sulfate on the expression of NLRP3 inflammasoma in monocytes from pre-eclamptic pregnant women, AP.R

• Abstract

  Periodontal disease is present in at least one tooth in 80% of the adult population of the world is a chronic oral infection that exposes the host to bacterial antigens and virulence factors, manifesting itself in two forms: gingivitis and chronic periodontitis and can cause to tooth loss.  Periodontal disease, is also associated to clinical complications, such as cardiovascular problems,…

  Conditions of oral health of pregnancy from Botucatu (São Paulo State) and its knowledge about the importance of oral health in pregnancy, AP.R
• Early and late preeclampsia differentiation by heat shock proteins determination, AP.R

(Only some records are available in English at this moment)

• Abstract

  Introduction: Pre-eclampsia (PE) is a pregnancy-specific syndrome, characterized by an intense systemic inflammatory response, which appears to contribute significantly to the pathophysiology of the disease. Monocytes from the peripheral blood of pregnant women with PE are endogenously activated and polarized towards an inflammatory profile, with an exacerbated production of pro-inflammat…

  INVOLVEMENT OF TNF RECEPTORS IN MONOCYTES POLARIZATION FROM PREGNANT WOMEN WITH PREECLAMPSIA, BP.MS

• Abstract

  Introduction: Evidence in the literature shows that magnesium sulfate (MgSO4) is the medication of choice for the prevention and treatment of eclampsia, in addition to having an anti-inflammatory effect. The anti-inflammatory action of MgSO4 is demonstrated by its inhibitory effect on the production of pro-inflammatory cytokines such as IL-1beta, IL-6, and TNF-alpha in pregnant women with…

  MODULATORY EFFECT OF MAGNESIUM SULFATE ON NLRP3 INFLAMMASOME EXPRESSION BY HUMAN MONOCYTES STIMULATED IN VITRO WITH MONOSODIUM URATE, BP.IC

• Abstract

  Hypertensive disorders determine repeated hospitalizations, greater length of stay for control of blood pressure and its complications, increased rates of hospitalization in intensive care unit so for the mother and the newborn, with demand special care and specialized professionals, which increases hospital costs. The present study aims to identify and analyze the costs of care for hyper…

  Cost of prenatal care of hypertensive pregnant women in university hospital of São Paulo, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Introduction: PE is characterized by systemic inflammation and an imbalance between angiogenic and antiangiogenic factors. The deficient invasion of trophoblast cells into the maternal endometrium is a key factor in the pathogenesis of PE, leading to hypoxia, oxidative stress, and an exaggerated maternal immune response. However, the precise mechanisms underlying this inadequate trophobla…

  3D IN VITRO MODEL OF PLACENTAL IMPLANTATION USING FIRST-TRIMESTER TROPHOBLAST CELLS, BE.EP.MS