CV Lattes
ResearcherID
ORCID
Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Odontologia (FOAr) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Odontologia Integral from Universidade Estadual Paulista Júlio de Mesquita Filho (1988), master's at Morphology from Universidade Federal de São Paulo (1995) and doctorate at Morphology from Universidade Federal de São Paulo (2000). He is currently orientador - pós-graduação em morfologia at Universidade Federal de São Paulo. Has experience in Morphology, acting on the following subjects: morfometria, imuno-histoquímica, apoptose, biocompatibilidade and materiais endodônticos. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Periodontitis causes an increase in several bioactive agents such as interleukins (IL), tumor necrosis factor (TNF)-± and receptor activator of NF-kB ligand (RANKL), which induce the osteoclast formation and activity. Since diacerein exerts anti-TNF-± and anti-IL-1 effects, alleviating bone destruction in osteoarthritis, we investigated whether this drug inhibits the formation and surviva…
Periodontitis (P), triggered by subgingival bacterial accumulation, causes the periodontal tissues degradation (gingiva, cementum, periodontal ligament and bone alveolar). Bone loss is considered as hallmark of progression of P. Therefore, the bone loss resulting of P is closely associated with osteoclast formation, activity and survival. Cytokines such as interleukin-1 (IL-1), IL-6, tumo…
The degradation of tissues of the eruptive pathway occurs during tooth eruption, including the lamina propria and bone located between tooth germ and oral mucosa. The eruptive pathway degradation depends on a complex cascade of cellular and molecular events that occur at specific sites and time. It is known that TNF-± and IL-1 are involved in osteoclastogenesis and activation of metallopr…
(Only some records are available in English at this moment)
Periodontitis is a public health issue that can lead to tooth loss due to alveolar bone resorption, potentially causing nutritional and psychosocial problems. Since the resorption of periodontal tissues is mediated by inflammatory cytokines such as interleukins (IL), prostaglandins, and matrix metalloproteinases (MMPs), studies have been conducted to develop therapies that modulate the im…
Periodontitis (P) is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, including bone resorption mediated by osteoclasts. Systemic diseases such as type 2 diabetes mellitus (T2DM), cardiovascular, and immunological disorders can aggravate its progression by dysregulating the immune response and increasing susceptibility to infection, in a bidirec…
Periodontitis (P) and type 2 diabetes mellitus (T2DM) are complex and multifactorial chronic diseases, characterized by a hyper-inflammatory state. The immunoinflammatory state promotes the recruitment of specific cells that release mediators, such as interleukin-1² (IL-1²), IL-6, IL-7, tumor necrosis factor-alpha (TNF-±), and matrix metalloproteinases (MMPs). Therefore, the modulation of…
The evaluation of the biological behavior for the formation of mineralized tissue of reparative materials in direct contact with dental pulp is of paramount importance in the field of dentistry. These materials are commonly employed in restorative procedures, where it is crucial to protect and preserve the integrity of dental pulp. The aim of this study will be to evaluate in vivo the bio…
Periodontitis is an immunoinflammatory disease characterized by recruitment of immune system cells that release mediators, such as tumour necrosis factor-alpha (TNF-±), interleukin-1² (IL-1²), IL-6 and matrix metalloproteinases. These cytokines promote degradation of extracellular matrix components as well as osteoclast formation and activity, culminating in the bone loss. Therefore, the …
Periodontitis (P) is a multifactorial and immunoinflammatory disease that culminates with the degradation of periodontal tissues (soft and hard tissues). P progression is under a complex control of several mediators including interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-±), matrix metalloproteinases (MMPs). These mediators promote the osteoclast formation, differentiation and ac…
(Only some records are available in English at this moment)