Abstract
Medication-induced osteonecrosis of the jaw (MRONJ) is a condition in which the patient has exposed bone for more than 8 weeks where they use of drugs as bisphosphonates and denosumab, without previous history of head and neck radiotherapy. These drugs act mainly by inhibiting bone resorption by inducing apoptosis in osteoclasts and inhibiting osteoclast differentiation, however, other e…