CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from Universidade Estadual Paulista Júlio de Mesquita Filho (1982) - UNESP, graduated in Biological Sciences teaching First Degree from Universidade Estadual Paulista Júlio de Mesquita Filho (1983), master's degree in Biological Sciences (Genetics) from UNESP (1990) and a PhD in Biological Sciences (Genetics) from Universidade Estadual Paulista Júlio de Mesquita Filho (1993). Full Professor in Molecular Genetics at UNESP (2022). She is currently an Adjunct Professor in the Department of Biological Sciences - IBILCE-UNESP, effective member - chancellor of the Brazilian Academy of Writers, coordinator of research groups - São Paulo Unit of Rede Bioética Brasil. She has experience in the area of Genetics, with an emphasis on Human and Medical Genetics, working mainly on the following topics: laboratory diagnosis, genetic diversity, polymorphism, hemoglobinopathies and prevention. (Source: Lattes Curriculum)
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AbstractSickle cell disease (SCD) is an inherited hemolytic anemia whose pathophysiology is driven by polymerization of the hemoglobin S (Hb S), leading to hemolysis and vaso-occlusive events. Inflammation is a fundamental component in these processes and a continuous inflammatory stimulus can lead to tissue damages. Thus, pro-resolving pathways emerge in order to restore the homeostasis.…
Iron plays a fundamental role in the functionality of tissues, being acquired through food and is absorbed by intestinal cells. Once absorbed, in the intracellular portion the iron groups together to form ferritin. Ferritin has the capacity to store more than 4,000 iron atoms and can be usedas a parameter to evaluate the level of intracellular iron. The overload of this mineralcauses hype…
Hemoglobinopathies are inherited hematological diseases of monogenic origin and autosomal recessive transmission. The term sickle disease (SCD) is used to represent a group of genetic disorders characterized by the presence of HbS, either in homozygosis, characterized by sickle cell anemia (SCA) recognized as the condition of greatest clinical significance within the group, or by its pres…
Sickle Cell Anemia (SCA), characterized by the presence of Hb S in homozygous, presents physiopathological events as hemolysis and vaso-occlusion, leading to ischemia-reperfusion injury with consequent clinical manifestations such as acute chest syndrome (ACS), crises of pain and priapism. These manifestations can be aggravated by genetic polymorphisms involved in some metabolic pathways …
Sickle cell disease (SCD) is the hemolytic anemias group with presence of hemoglobin S (Hb S), and includes sickle cell anemia, thalassemia interactions and associations with other hemoglobin variants. The interaction of HbS with beta-thalassemia (Hb S²-thalassemia) involves combinations that can result in variable phenotypes depending on the type of mutation for inherited beta thalassemi…
(Only some records are available in English at this moment)
Human activities have been considered the main causes of climate change (CC) observed in the world and effects of increases temperature, acidification and salinity in marine water bodies have been reported in benthonic fish. In the fish Solea senegalensis, for example, the water temperature is a basic abiotic factor that regulates its physiology and metabolism, since it inhabits coastal a…
| 5 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 20 / 17 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 27 / 21 | All research grants and scholarships |
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