| Texto completo | |
| Autor(es): |
Simis, Marcel
[1]
;
Camsari, Deniz Doruk
[2, 3]
;
Imamura, Marta
[1]
;
Filippo, Thais Raquel Martins
[4]
;
De Souza, Daniel Rubio
[1]
;
Battistella, Linamara Rizzo
[1]
;
Fregni, Felipe
[3]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Sao Paulo - Brazil
[2] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN - USA
[3] Harvard Med Sch, Neuromodulat Ctr, Spaulding Rehabil Hosp, Boston, MA 02115 - USA
[4] Univ Paulista Univ Nove Julho, Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN HUMAN NEUROSCIENCE; v. 15, APR 9 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Background Functional changes after spinal cord injury (SCI) are related to changes in cortical plasticity. These changes can be measured with electroencephalography (EEG) and has potential to be used as a clinical biomarker. Method In this longitudinal study participants underwent a total of 30 sessions of robotic-assisted gait training (RAGT) over a course of 6 weeks. The duration of each session was 30 min. Resting state EEG was recorded before and after 30-session rehabilitation therapy. To measure gait, we used the Walking Index for Spinal Cord Injury Scale, 10-Meter- Walking Test, Timed-Up-and-Go, and 6-Min-Walking Test. Balance was measured using Berg Balance Scale. Results Fifteen participants with incomplete SCI who had AIS C or D injuries based on American Spinal Cord Injury Association Impairment Scale classification were included in this study. Mean age was 35.7 years (range 17-51) and the mean time since injury was 17.08 (range 4-37) months. All participants showed clinical improvement with the rehabilitation program. EEG data revealed that high beta EEG activity in the central area had a negative correlation with gait (p = 0.049; beta coefficient: -0.351; and adj-R-2: 0.23) and balance (p = 0.043; beta coefficient: -0.158; and adj-R-2:0.24) measured at baseline, in a way that greater high beta EEG power was related to worse clinical function at baseline. Moreover, improvement in gait and balance had negative correlations with the change in alpha/theta ratio in the parietal area (Gait: p = 0.049; beta coefficient: -0.351; adj-R-2: 0.23; Balance: p = 0.043; beta coefficient: -0.158; and adj-R-2: 0.24). Conclusion In SCI, functional impairment and subsequent improvement following rehabilitation therapy with RAGT correlated with the change in cortical activity measured by EEG. Our results suggest that EEG alpha/theta ratio may be a potential surrogate marker of functional improvement during rehabilitation. Future studies are necessary to improve and validate these findings as a neurophysiological biomarker for SCI rehabilitation. (AU) | |
| Processo FAPESP: | 17/12943-8 - O déficit da inibição como marcador de neuroplasticidade na reabilitação |
| Beneficiário: | Felipe Fregni |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa SPEC |