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Efficacy of curcumin-mediated antibacterial photodynamic therapy for oral antisepsis: A systematic review and network meta-analysis of randomized clinical trials

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Autor(es):
Ferrisse, Tulio Morandin ; Dias, Luana Mendonca ; de Oliveira, Analu Barros ; Jordao, Claudia Carolina ; de Oliveira Mima, Ewerton Garcia ; Pavarina, Ana Claudia
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: Photodiagnosis and Photodynamic Therapy; v. 39, p. 9-pg., 2022-05-30.
Resumo

Background: The presence of oral microorganisms resistant to traditional treatment is increasing, thus a search for new therapies is needed. In this context, antimicrobial photodynamic therapy (aPDT) is an approach for the treatment of antibiotic resistant andnon resistant microorganisms. Therefore, the aim of the present study was to conduct a systematic review and meta-analysis of randomized clinical trials of aPDT for oral antisepsis against oral polymicrobial biofilms. Methods: PubMed, Science Direct, Scopus, SciELO, Lilacs, Cochrane Library and Embase databases were searched. In total, five articles were included for qualitative analysis and four articles were used for quantitative analyses. Bias assessment of the eligible articles was made using the RoB 2 criteria. Network meta-analysis was performed using the random-effect model. Subgroup's analysis was also conducted. The groups evaluated were aPDT, exposure to light only and no treatment at all (control group). The quality of evidence was assessed by CINeMA approach. Results: aPDT mediated by curcumin had significant results in the reducing bacterial load (0.31-0.49 log(10) UFC/I-2=0%) when compared with the control group. The included articles were classified as low risk of bias, despite biases detected by allocation and blinding. Moreover, quantitative analysis between aPDT and control group and between light and control group were classified with low risk of confidence rating, while the results from aPDT versus light were classified as moderate risk of confidence rating. Conclusion: aPDT has significant efficacy for oral antisepsis, however more randomized clinical trials will be needed to validate the present results. (AU)

Processo FAPESP: 20/07110-0 - Potencial da terapia fotodinâmica na modulação da resposta inflamatória e nos fatores de virulência microbianos: avaliação em modelo de co-culturas tridimensionais de fibroblastos gengivais, Candida albicans e Staphylococcus aureus
Beneficiário:Analú Barros de Oliveira
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 21/01191-0 - Indução de tolerância e caracterização do biofime de Candida albicans submetido à terapia fotodinâmica antimicrobiana
Beneficiário:Túlio Morandin Ferrisse
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
Beneficiário:Vanderlei Salvador Bagnato
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 20/16227-8 - Influência da terapia fotodinâmica combinada com peptídeos antimicrobianos sobre biofilmes de Candida albicans e cultura 3D de células
Beneficiário:Luana Mendonça Dias Santana
Modalidade de apoio: Bolsas no Brasil - Doutorado