Synthesis of Glycal Amides from Amino Acid Esters by Carbonylative Coupling Reaction

Autor(es)

De Jesus, Jessica C. ; Noguchi, Henrique K. ; Toledo, Monica F. Z. J. ; Burrow, Robert A. ; Pimenta, Daniel C. ; Stefani, Helio A.

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2022, n. 30, p. 7-pg., 2022-08-12.

Resumo

Glycal amides were prepared for the first time by reacting 2-iodo-D-glycals with L-amino acid esters via a Pd-catalyzed carbonylative cross-coupling reaction, by using Mo(CO)(6) as the carbon monoxide source. Glycal amides were synthesized in moderate to good yields under our optimized conditions. In addition, the acetyl groups of the glucal amides could be readily removed to obtain the corresponding trihydroxy derivatives in good yields. (AU)

• Processo FAPESP: 20/00295-4 - Funcionalização de D-glucal e análogos via reação de acoplamento carbonbilativo
• Beneficiário: Helio Alexandre Stefani
• Modalidade de apoio: Auxílio à Pesquisa - Regular