An Update on the Synthesis and Pharmacological Properties of Pyrazoles Obtained

Autor(es)

Queiroz, Jaqueline E. ; Dias, Lucas D. ; Vila Verde, Giuliana M. ; Aquino, Gilberto L. B. ; Camargo, Ademir J.

• Tipo de documento: Artigo Científico
• Fonte: CURRENT ORGANIC CHEMISTRY; v. 26, n. 2, p. 10-pg., 2022-01-01.

Resumo

A review concerning the synthesis and pharmacological properties of pyrazoles obtained from Chalcone described in the literature over the last 5 years (2016-2020) was presented and discussed. Among the synthetic approaches for pyrazoles described so far, the cyclization and acetylation method of alpha,beta-unsaturated chalcones, and substituted hydrazine were selected and analyzed. 105 pyrazole derivatives (3-107) were evaluated as well as their pharmacological activities, namely, antineoplastic, anti-inflammatory, antioxidant, antibacterial, antifungal, antimycobacterial, antiplasmodial, Alzheimer's disease, enzymes inhibition (like acetylcholinesterase, carbonic anhydrase, and malonyl CoA decarboxylase), anticonvulsant, among others. Pyrazolic compounds are widely used in the design of the new drug with a wide spectrum of pharmacological approaches. Therefore, it is relevant to research the synthetic methods and therapeutic properties of different pyrazole derivatives. (AU)

• Processo FAPESP: 19/13569-8 - Estudo dos Mecanismos de Ação em Terapia Fotodinâmica: Do Fotossensibilizador à Aplicação Prática
• Beneficiário: Lucas Danilo Dias
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado