| Texto completo | |
| Autor(es): |
de Oliveira Braga, Lucia Elaine
;
da Silva, Gisele Goulart
;
de Oliveira Sousa, Ilza Maria
;
Souza de Oliveira, Ellen Cristina
;
Jorge, Michele Pedroza
;
Monteiro, Karin Maia
;
Sedano, Tamires Carolina
;
Foglio, Mary Ann
;
Tasca Gois Ruiz, Ana Lucia
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INFLAMMOPHARMACOLOGY; v. 30, n. 6, p. 11-pg., 2022-04-22. |
| Resumo | |
Found in humid regions and waterways and popularly used to treat gastrointestinal problems among other applications, the present study evaluated the M. aquatica essential oil (OEMa) as a therapeutic alternative to treat gastrointestinal disorders. Produced by steam distillation, chemical composition of OEMa was determined by GC-MS analysis. The ethanol-induced ulcer and the dose-repeated acetylsalicylic acid (ASA)-induced gastrointestinal lesions models in rats evaluated, respectively, the prophylactic and curative effects of EOMa on peptic ulcers. The EOMa's effect on gastric secretion, gastric mucus and gastrointestinal motility were evaluated in in vivo models. The curative effect of EOMa on acute colitis was evaluated using the DSS-induced colitis model in mice. Obtained in 0.17% yield (w/w), with carvone (54.82 +/- 1.39 g/100 g oil) as the main constituent, EOMa (at 75 mg/kg) showed potent gastroprotective effect (> 90%) mediated by non-protein sulfhydryl compounds (NPSH) and nitric oxide (NO) modulation alongside reduction in gastric secretion volume and total acidity. EOMa did not affect gastric mucus production and gastrointestinal motility. In dose-repeated ASA-induced gastrointestinal lesions model, EOMa (at 25 mg/kg) promoted the inflammatory process resolution both in gastric and duodenal walls by modulating NPSH, NO and myeloperoxidase levels. Despite delaying in 2 days the clinical symptoms worsening, EOMa (at 25 mg/kg) was not able to protect colon tissues from DSS-induced acute colitis as evidenced by macroscopic, biochemical, and histopathological parameters. This is the first report of Mentha aquatica essential oil as a promising herbal medicine for peptic ulcers treatment together with an adjuvant effect in IBD. (AU) | |
| Processo FAPESP: | 11/01114-4 - Atividade antiproliferativa e ação hormonal/anti-hormonal de extratos e frações enriquecidas de algumas espécies de Mentha (Lamiaceae) |
| Beneficiário: | Ana Lúcia Tasca Gois Ruiz |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/23950-7 - Avaliação da atividade (anti)mutagênica in vitro de um alcaloide aporfínico e seus intermediários de síntese |
| Beneficiário: | Tamires Carolina Sedano |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |