| Texto completo | |
| Autor(es): |
Rocha, Rodrigo P.
;
Kocillari, Loren
;
Suweis, Samir
;
De Grazia, Michele De Filippo
;
de Schotten, Michel Thiebaut
;
Zorzi, Marco
;
Corbetta, Maurizio
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURE COMMUNICATIONS; v. 13, n. 1, p. 18-pg., 2022-06-27. |
| Resumo | |
The critical brain hypothesis states that biological neuronal networks, because of their structural and functional architecture, work near phase transitions for optimal response to internal and external inputs. Criticality thus provides optimal function and behavioral capabilities. We test this hypothesis by examining the influence of brain injury (strokes) on the criticality of neural dynamics estimated at the level of single participants using directly measured individual structural connectomes and whole-brain models. Lesions engender a sub-critical state that recovers over time in parallel with behavior. The improvement of criticality is associated with the re-modeling of specific white-matter connections. We show that personalized whole-brain dynamical models poised at criticality track neural dynamics, alteration post-stroke, and behavior at the level of single participants. The authors investigate the influence of brain injury (strokes) on the criticality of neural dynamics using directly measured connectomes and whole-brain models. They show that lesions engender a sub-critical state that recovers over time in parallel with behavior. (AU) | |
| Processo FAPESP: | 18/08609-8 - Mapeando a representação cortical da postura em pacientes com acidente vascular cerebral |
| Beneficiário: | Rodrigo Pereira Rocha |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |