Bioactive Glasses as Carriers of Cancer-Targeted Drugs: Challenges and Opportunities in Bone Cancer Treatment

Autor(es)

Borges, Roger ; Pelosine, Agatha Maria ; de Souza, Ana Carolina Santos ; Machado Jr, Joel ; Justo, Giselle Zenker ; Gamarra, Lionel Fernel ; Marchi, Juliana

• Tipo de documento: Artigo Científico
• Fonte: MATERIALS; v. 15, n. 24, p. 25-pg., 2022-12-01.

Resumo

The treatment of bone cancer involves tumor resection followed by bone reconstruction of the defect caused by the tumor using biomaterials. Additionally, post-surgery protocols cover chemotherapy, radiotherapy, or drug administration, which are employed as adjuvant treatments to prevent tumor recurrence. In this work, we reviewed new strategies for bone cancer treatment based on bioactive glasses as carriers of cancer-targeted and other drugs that are intended for bone regeneration in conjunction with adjuvant treatments. Drugs used in combination with bioactive glasses can be classified into cancer-target, osteoclast-target, and new therapies (such as gene delivery and bioinorganic). Microparticulated, nanoparticulated, or mesoporous bioactive glasses have been used as drug-delivery systems. Additionally, surface modification through functionalization or the production of composites based on polymers and hydrogels has been employed to improve drug-release kinetics. Overall, although different drugs and drug delivery systems have been developed, there is still room for new studies involving kinase inhibitors or antibody-conjugated drugs, as these drugs have been poorly explored in combination with bioactive glasses. (AU)

• Processo FAPESP: 20/00329-6 - Desenvolvimento de compósito multifuncional injetável para tratamento de câncer ósseo por hipertermia e braquiterapia associado à reparação óssea
• Beneficiário: Juliana Marchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/16512-9 - Desenvolvimento de um sistema carreador para liberação simultânea de fármaco e íons provenientes de vidros biocompatíveis a partir de uma matriz de hidrogel com os objetivos de auxiliar no tratamento de câncer ósseo e estimular a reparação óssea
• Beneficiário: Juliana Marchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular