Exploiting synergistic effects: Cheap ultra-sensitive electrochemical rutin detection using WO3/rGO nanocomposite in combination with multiwalled carbon nanotubes

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Neto, Antonio Gomes dos Santos ; Santos, Ana Caroline Ferreira ; Junior, Jose Antonio de Oliveira ; Jost, Cristiane Luisa ; Sousa, Camila Silva de ; Goulart, Marilia Oliveira Fonseca ; Santana, Antonio Euzebio Goulart ; Gonzalez, Sergio Yesid Gomez ; Silva, Ederson Esteves da ; Fonsaca, Jessica Eliza Silva ; Domingues, Sergio Humberto ; Dall'Oglio, Daiane Fossatti ; Vitorino, Hector Aguilar ; Tanaka, Auro Atsushi ; Morawski, Franciele de Matos ; Garcia, Marco Aurelio Suller

• Tipo de documento: Artigo Científico
• Fonte: Microchemical Journal; v. 193, p. 10-pg., 2023-10-01.

Resumo

Multiwalled carbon nanotubes (MWCNTs) are extensively studied due to their enhanced signal response, improved stability, selectivity, and versatility in fabrication, especially combined with designed materials; however, costly and time-consuming preparation are obstacles to their implementation in routine analyses. Therefore, we propose a tungsten oxide (WO3) and reduced graphene oxide (rGO) nanocomposite (WO3-G/ MWCNT) that was mixed with MWCNTs and presented interesting results. We prepared the nanocomposite using a fast and facile route using in situ generated atomic hydrogen species; also, it was easily characterized by Scanning Electron Microscopy, Raman, and X-ray Spectroscopy. The nanocomposite was deposited on a glassy carbon electrode (GCE) and investigated as a voltammetric sensor for ultra-sensitive rutin quantification; a synergic effect towards rutin oxidation was observed by a 30-fold current increase in comparison to the bare GCE. Under optimized conditions, square wave voltammetry was performed, presenting a linear range from 0.183 to 2.849 & mu;mol/L. The limits of detection and quantification were 9.00 and 65.00 nmol/L, respectively. High selectivity was noticed in quantifying 1.75 & mu;mol/L rutin in the presence of ascorbic acid, citric acid, caffeine, glucose, and naringenin, which was attributed to the high signal response and sensitivity of WO3-G/ MWCNT/GCE. High accuracy was also noticed for determining rutin in synthetic human serum and commercial plasma samples, with a recovery range of 85.5-108.7%. Those results confirm that the easy fabrication of WO3G/MWCNT can be an excellent alternative for manufacturing ultra-sensitive sensors with promising features to be explored for drug monitoring and quality control of pharmaceuticals. (AU)

• Processo FAPESP: 20/13288-6 - Materiais bidimensionais e seus derivados para biossensoriamento fotônico de patógenos
• Beneficiário: Jéssica Eliza Silva Fonsaca
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado