Efficient Treatment of Fish Intestinal Parasites Applying a Membrane-Penetrating Oral Drug Delivery Nanoparticle

Autor(es)

Mathews, Patrick D. D. ; Patta, Ana C. M. F. ; Madrid, Rafael R. M. ; Ramirez, Carlos A. B. ; Pimenta, Barbara V. V. ; Mertins, Omar

• Tipo de documento: Artigo Científico
• Fonte: ACS BIOMATERIALS SCIENCE & ENGINEERING; v. 9, n. 6, p. 13-pg., 2021-11-15.

Resumo

Nanodelivery of drugs aims to ensuredrug stability in the faceof adverse biochemical conditions in the course of administration,concomitant with appropriate pharmacological action provided by deliveryat the targeted site. In this study, the application potential ofa nanoparticle produced with biopolymers chitosan-N-arginine and alginate as an oral drug delivery material is evaluated.Both macromolecules being weak polyelectrolytes, the nanoparticlepresents strong thermodynamic interactions with a biological modelmembrane consisting of a charged lipid liposome bilayer, leading tomembrane disruption and membrane penetration of the nanoparticlesin ideal conditions of pH corresponding to the oral route. The powderform of the nanoparticle was obtained by lyophilization and with ahigh percentage of entrapment of the anthelmintic drug praziquantel.In vivo studies were conducted with oral administration to Corydoras schwartzi fish with high intensity of intestinalparasites infection. The in vivo experiments confirmed the mucoadhesiveand revealed membrane-penetrating properties of the nanoparticle bytranslocating the parasite cyst, which provided target drug releaseand reduction of over 97% of the fish intestinal parasites. Thus,it was evidenced that the nanoparticle was effective in transportingand releasing the drug to the target, providing an efficient treatment. (AU)

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