Current Trends on Bioengineering Approaches for Ovarian Microenvironment Reconstruction

Autor(es)

Almeida, Gustavo Henrique Dona Rodrigues ; Iglesia, Rebeca Piatniczka ; Rinaldi, Jaqueline de Carvalho ; Murai, Mikaelly Kiemy ; Calomeno, Celso Vitor Alves Queiroz ; da Silva Junior, Leandro Norberto ; Horvath-Pereira, Bianca de Oliveira ; Pinho, Leticia Beatriz Mazo ; Miglino, Maria Angelica ; Carreira, Ana Claudia Oliveira

• Tipo de documento: Artigo Científico
• Fonte: TISSUE ENGINEERING PART B-REVIEWS; v. 29, n. 3, p. 39-pg., 2023-03-09.

Resumo

Ovarian tissue has a unique microarchitecture and a complex cellular and molecular dynamics that are essential for follicular survival and development. Due to this great complexity, several factors may lead to ovarian insufficiency, and therefore to systemic metabolic disorders and female infertility. Techniques currently used in the reproductive clinic such as oocyte cryopreservation or even ovarian tissue transplant, although effective, have several limitations, which impair their wide application. In this scenario, mimetic ovarian tissue reconstruction comes as an innovative alternative to develop new methodologies for germ cells preservation and ovarian functions restoration. The ovarian extracellular matrix (ECM) is crucial for oocyte viability maintenance, once it acts actively in folliculogenesis. One of the key components of ovarian bioengineering is biomaterials application that mimics ECM and provides conditions for cell anchorage, proliferation, and differentiation. Therefore, this review aims at describing ovarian tissue engineering approaches and listing the main limitations of current methods for preservation and reestablishment of ovarian fertility. In addition, we describe the main elements that structure this study field, highlighting the main advances and the challenges to overcome to develop innovative methodologies to be applied in reproductive medicine. Impact StatementThis review presents the main advances in the application of tissue bioengineering in the ovarian tissue reconstruction to develop innovative solutions for ovarian fertility reestablishment. (AU)

• Processo FAPESP: 14/50844-3 - Matriz extracelular na saúde e matriz placentária na regeneração de tecidos
• Beneficiário: Maria Angelica Miglino
• Modalidade de apoio: Auxílio à Pesquisa - Temático