Photobiomodulation and Inorganic Bovine Bone in Guided Bone Regeneration: Histomorphometric Analysis in Rats

Autor(es)

de Freitas, Nicole Rosa ; Guerrini, Luisa Belluco ; Esper, Luis Augusto ; Sbrana, Michyele Cristhiane ; dos Santos, Caroline Chepernate Vieira ; de Almeida, Ana Lucia Pompeia Fraga

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF FUNCTIONAL BIOMATERIALS; v. 14, n. 5, p. 13-pg., 2023-05-18.

Resumo

The objective of this study was to evaluate the efficacy of photobiomodulation in the bone regeneration of critical-sized defects (CSD) filled with inorganic bovine bone associated or not with collagen membranes. The study has been conducted on 40 critical defects in the calvaria of male rats, divided into four experimental groups (n = 10): (1) DBBM (deproteinized bovine bone mineral); (2) GBR (DBBM+collagen membrane); (3) DBBM+P (DBBM+photobiomodulation); and (4) GBR+P (GBR+photobiomodulation). At 30 days postoperative, the animals were euthanized, and after the tissue had been processed, histological, histometric, and statistical analyses were performed. The analyses have taken into account newly formed bone area (NBA), linear bone extension (LBE), and residual particle area (RPA) as variables. The Kruskal-Wallis test has been performed, followed by the Dwass-Steel-Critchlow-Fligner test for comparison between groups (p < 0.05). When the DBBM+P group was compared to the DBBM group, it was possible to observe significant statistical differences in all the variables analyzed (p < 0.05). The application of photobiomodulation in guided bone regeneration (GBR+P) has shown a decrease in the median value for the RPA variable (26.8) when compared to the GBR group (32.4), with a significant statistical difference; however, for NBA and LBE, the therapy has not provided significant results. (AU)

• Processo FAPESP: 10/13170-3 - Avaliação da cicatrização de defeitos ósseos criados cirurgicamente em calvárias de ratos tratados com enxertos de origem bovina (Bio-Oss) associados ao laser de baixa intensidade. Estudo histológico e histométrico
• Beneficiário: Mércia Jussara da Silva Cunha
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/00779-2 - Avaliação da cicatrização de defeitos ósseos criados cirurgicamente em calvárias de ratos tratados com enxerto ósseo autógeno associado ao laser de baixa intensidade. Estudo histológico e histométrico.
• Beneficiário: Isabella Luzia Medeiros
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica