Paper-based analytical devices for point-of-need applications

Autor(es)

Pradela-Filho, Lauro A. ; Veloso, William B. ; Arantes, Iana V. S. ; Gongoni, Juliana L. M. ; de Farias, Davi M. ; Araujo, Diele A. G. ; Paixao, Thiago R. L. C.

• Tipo de documento: Artigo Científico
• Fonte: Microchimica Acta; v. 190, n. 5, p. 23-pg., 2023-05-01.

Resumo

Paper-based analytical devices (PADs) are powerful platforms for point-of-need testing since they are inexpensive devices fabricated in different shapes and miniaturized sizes, ensuring better portability. Additionally, the readout and detection systems can be accomplished with portable devices, allying with the features of both systems. These devices have been introduced as promising analytical platforms to meet critical demands involving rapid, reliable, and simple testing. They have been applied to monitor species related to environmental, health, and food issues. Herein, an outline of chronological events involving PADs is first reported. This work also introduces insights into fundamental parameters to engineer new analytical platforms, including the paper type and device operation. The discussions involve the main analytical techniques used as detection systems, such as colorimetry, fluorescence, and electrochemistry. It also showed recent advances involving PADs, especially combining optical and electrochemical detection into a single device. Dual/combined detection systems can overcome individual barriers of the analytical techniques, making possible simultaneous determinations, or enhancing the devices' sensitivity and/or selectivity. In addition, this review reports on distance-based detection, which is also considered a trend in analytical chemistry. Distance-based detection offers instrument-free analyses and avoids user interpretation errors, which are outstanding features for analyses at the point of need, especially for resource-limited regions. Finally, this review provides a critical overview of the practical specifications of the recent analytical platforms involving PADs, demonstrating their challenges. Therefore, this work can be a highly useful reference for new research and innovation. (AU)

• Processo FAPESP: 21/00205-8 - Dispositivos analíticos miniaturizados e/ou microfluídicos para aplicações biológicas
• Beneficiário: Lauro Antonio Pradela Filho
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/15065-7 - Desenvolvimento de sistemas eletroquímicos em papel voltados para análises em fluxo de amostras de interesse forense
• Beneficiário: Iana Vitória Spadini Arantes
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 22/11346-4 - Sistemas microfluídicos impressos em 3D para aplicações analíticas biológicas
• Beneficiário: Lauro Antonio Pradela Filho
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado