Antifungal Applications of Ag-Decorated Hydroxyapatite Nanoparticles

Autor(es)

Zamperini, C. A. ; Andre, R. S. ; Longo, V. M. ; Mima, E. G. ; Vergani, C. E. ; Machado, A. L. ; Varela, J. A. ; Longo, E.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Nanomaterials; v. 2013, p. 9-pg., 2013-01-01.

Resumo

Pure hydroxyapatite (HA) and hydroxyapatite decorated with silver (HA@Ag) nanoparticles were synthesized and characterized. The antifungal effect of HA@Ag nanoparticles in a distilled water solution was evaluated against Candida albicans. The origin of the antifungal activity of the HA@Ag is also discussed. The results obtained showed that the HA nanorod morphology remained the same with Ag ions decorations on the HA structure which were deposited in the form of nanospheres. Interaction where occurred between the structure and its defect density variation in the interfacial HA@Ag and intrafacial HA region with the fungal medium resulted in antifungal activity. The reaction mechanisms involved oxygen and water adsorption which formed an active complex cluster. The decomposition and desorption of the final products as well as the electron/hole recombination process have an important role in fungicidal effects. (AU)

• Processo FAPESP: 11/24004-0 - Síntese, caracterização e propriedades antimicrobianas de soluções de nanopartículas de TiO2 e TiO2:Ag e efeito antimicrobiano de biomateriais inorgânicos revestidos com essas nanopartículas
• Beneficiário: Ana Lucia Machado
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/06786-0 - Síntese, caracterização e propriedades antimicrobianas de soluções de nanopartículas de TiO2 e TiO2:Ag e efeito antimicrobiano de biomateriais revestidos com essas nanopartículas
• Beneficiário: Camila Andrade Zamperini Navarro
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado