An Electrochemical Sensor for the Simultaneous Determination of Paracetamol and Codeine Using a Glassy Carbon Electrode Modified with Nickel Oxide Nanoparticles and Carbon Black

Autor(es)

Deroco, Patricia Batista ; Vicentini, Fernando Campanha ; Fatibello-Filho, Orlando

• Tipo de documento: Artigo Científico
• Fonte: Electroanalysis; v. 27, n. 9, p. 7-pg., 2015-09-01.

Resumo

In this work, a simple and highly selective voltammetric method was developed for the simultaneous determination of paracetamol (PCT) and codeine (COD) in pharmaceuticals and human body fluids employing a glassy carbon electrode modified with carbon black (CB) and nickel oxide nanoparticles (NiONPs) within a dihexadecylphosphate (DHP) film. Using square-wave voltammetry (SWV), a separation of ca. 550 mV between the oxidation peak potentials of PCT and COD was obtained. The simultaneous determination of PCT and COD presented a linear concentration range from 3.0 to 47.8 mu mol L-1 for PCT and from 0.83 to 38.3 mu mol L-1 for COD. (AU)

• Processo FAPESP: 13/16770-0 - Desenvolvimento de sensores à base de filmes poliméricos e nanomateriais para aplicações analíticas diversas
• Beneficiário: Fernando Campanhã Vicentini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/07919-2 - Preparação de eletrodos com novos materiais à base de carbono para aplicações em eletroanalítica
• Beneficiário: Patrícia Batista Deroco
• Modalidade de apoio: Bolsas no Brasil - Doutorado