Toxoplasma gondii in cetaceans of Brazil: a histopathological and immunohistochemical survey

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Costa-Silva, Samira ; Sacristan, Carlos ; Gonzales-Viera, Omar ; Diaz-Delgado, Josue ; Sanchez-Sarmiento, Angelica Maria ; Marigo, Juliana ; Groch, Katia Regina ; Carvalho, Vitor Luz ; Ewbank, Ana Carolina ; Colosio, Adriana Castaldo ; Calzavara Marcondes, Milton Cesar ; Oliveira de Meirelles, Ana Carolina ; Bertozzi, Carolina P. ; Lailson-Brito, Jose ; Azevedo, Alexandre de Freitas ; Ruoppolo, Valeria ; Oliveira, Larissa ; Ott, Paulo Henrique ; Catao-Dias, Jose Luiz

• Tipo de documento: Artigo Científico
• Fonte: REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA; v. 28, n. 3, p. 8-pg., 2019-07-01.

Resumo

Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. In cetaceans, T gondii infection is a significant cause of morbidity and mortality. Despite the worldwide range and broad cetacean host record of T gondii infection, there is limited information on toxoplasmosis in cetaceans from the Southern hemisphere. We investigated the occurrence of T gondii by histopathology and immunohistochemistry in tissue samples of 185 animals comprising 20 different cetacean species from Brazil. Three out of 185 (1.6%) animals presented T gondii-associated lesions: a captive killer whale Orcinus orca, a free-ranging common bottlenose dolphin Tursiops truncatus and a free-ranging Guiana dolphin Sotalia guianensis. The main lesions observed in these animals were necrotizing hepatitis, adrenalitis and lymphadenitis associated with protozoal cysts or extracellular tachyzoites presenting immunolabcling with anti- T gondii antibodies. This study widens the spectrum of species and the geographic range of this agent in Brazil, and provides the first reports of T gondii infection in a captive killer whale and in a free-ranging common bottlenose dolphin in South America. (AU)

• Processo FAPESP: 17/02223-8 - Imunopatologia comparativa da infecção por Morbillivirus nos cetáceos: estudos histológico, imuno-histoquímico e molecular
• Beneficiário: Josué Díaz Delgado
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado