Development of a platform for the production of multiple modal chelating and imaging agents using desferrioxamine and bovine albumin as a model

Autor(es)

Correia, Lucas Antonio Arias ; Garcia, Rodrigo Santos ; Real, Caroline Cristiano ; Uzueli, Daniel Henrique ; Sa, Ulisses Lacerda de Figueiredo ; Marques, Fabio Luiz Navarro ; Colnago, Luiz Alberto ; Esposito, Breno Pannia

• Tipo de documento: Artigo Científico
• Fonte: CHEMICAL PAPERS; v. 75, n. 3, p. 7-pg., 2020-09-30.

Resumo

The linker p-SCN-Bz-desferrioxamine was used as a conjugating agent to bovine serum albumin. The conjugate (BSA-DFO) did not display relevant structural alterations in comparison with the native protein. BSA-DFO was able to bind iron in a high affinity, antioxidant form similar to the native siderophore desferrioxamine. The gadolinium complex of BSA-DFO displayed 7-10 times higher relaxivities compared to the low molecular weight complex. Preparation of the radiotracers(68)Ga(BSA-DFO) and(89)Zr(BSA-DFO) in high radiochemical yields was accomplished quickly in mild conditions. These results indicate that BSA-DFO might be useful as an alternative treatment for iron overload disorders, and as a platform for the production of radiotracers or contrast agents for magnetic resonance imaging. (AU)

• Processo FAPESP: 16/03709-9 - Modulação dos níveis e da reatividade do ferro fisiológico por novos quelantes naturais ou bifuncionais: possíveis aplicações na saúde humana
• Beneficiário: Breno Pannia Esposito
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/16379-0 - Conjugados desferrioxamina: albumina para a terapia de sobrecarga de ferro
• Beneficiário: Lucas Antonio Arias Correia
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica