| Texto completo | |
| Autor(es): |
Silva, Caroline E. P.
;
Picco, Agustin S.
;
Galdino, Flavia Elisa
;
de Burgos Martins de Azevedo, Mariangela
;
Cathcarth, Marilina
;
Passos, Aline R.
;
Cardoso, Mateus Borba
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Nano Letters; v. 24, n. 42, p. 7-pg., 2024-10-01. |
| Resumo | |
In biological systems, nanoparticles interact with biomolecules, which may undergo protein corona formation that can result in noncontrolled aggregation. Therefore, comprehending the behavior and evolution of nanoparticles in the presence of biological fluids is paramount in nanomedicine. However, traditional lab-based colloid methods characterize diluted suspensions in low-complexity media, which hinders in-depth studies in complex biological environments. Here, we apply X-ray photon correlation spectroscopy (XPCS) to investigate silica nanoparticles (SiO2) in various environments, ranging from low to high complex biological media. Interestingly, SiO2 revealed Brownian motion behavior, irrespective of the complexity of the chosen media. Moreover, the SiO2 surface and media composition were tailored to underline the differences between a corona-free system from protein corona and aggregates formation. Our results highlighted XPCS potential for real-time nanoparticle analysis in biological media, surpassing the limitations of conventional techniques and offering deeper insights into colloidal behavior in complex environments. (AU) | |
| Processo FAPESP: | 20/00767-3 - Desenvolvimento de formulações de nanopartículas em pó com excelente redispersibilidade: enfrentando um grande desafio na Nanomedicina |
| Beneficiário: | Mateus Borba Cardoso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/12071-6 - Arquitetando coloides via interações supramoleculares: de fundamentos a aplicações |
| Beneficiário: | Watson Loh |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 23/02144-1 - Dinâmica de nanopartículas de sílica em fluidos biológicos complexos através da técnica de XPCS |
| Beneficiário: | Caroline Ezequiel de Paulo da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |