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Development of surface-treated poly(lactic acid)/zinc oxide biocomposites for 3D printing in bone tissue engineering

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Autor(es):
Marega, Felippe Migliato ; Klok, Larissa Aline ; Steffen, Teresa Tromm ; Cunha, Daniel A. L. V. ; Harb, Samarah V. ; Kolanthai, Elayaraja ; Seal, Sudipta ; Becker, Daniela ; Pessan, Luiz Antonio ; Costa, Lidiane Cristina
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: Journal of Applied Polymer Science; v. 141, n. 38, p. 16-pg., 2024-07-08.
Resumo

The increase in bone fractures has been driving the development of materials for bone repair with better mechanical and biological properties. This work reports the development of poly (lactic acid) (PLA)-zinc oxide (ZnO) biocomposites for 3D printing of scaffolds to be applied in bone tissue engineering. The ZnO surface was functionalized with maleic anhydride (ZnOMA) by applying radio frequency plasma treatment as an alternative to control the catalytic effects of ZnO on the degradation of the PLA during the molten state processing. PLA and ZnOMA powders were processed using a heated internal mixer and the resulted biocomposites were used to manufacture scaffolds by 3D printing. The scaffolds were characterized by their rheological, thermal, microstructural, mechanical, and biological properties. Compositions containing ZnOMA presented higher viscosities, evidencing the control of degradation by surface functionalization, and achieved an elastic modulus near 1 GPa, suitable for bone applications, unlike the untreated samples. In relation to cell functions, PLA-ZnOMA scaffolds exhibited cell viabilities at 160%, compared to 50% for untreated samples and stimulated mesenchymal stem cells toward osteoblast. Therefore, ZnO's negative thermal degradation effect on PLA was successfully overcome using plasma functionalization, enabling the 3D printing of bioactive scaffolds with great potential for application in tissue engineering. Surface-treated poly(lactic acid)/zinc oxide scaffolds forbone tissue engineering. image (AU)

Processo FAPESP: 18/26060-3 - Scaffolds bioativos e bactericidas para regeneração óssea via impressão 3D
Beneficiário:Samarah Vargas Harb
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 17/09609-9 - Desenvolvimento de scaffolds bioinspirados de PLA/cargas cerâmicas bioativas via impressão 3D
Beneficiário:Luiz Antonio Pessan
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/27415-2 - Scaffolds bioativos com modificação superficial por plasma
Beneficiário:Luiz Antonio Pessan
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 17/11366-7 - Desenvolvimento de scaffolds bioinspirados de PLA/biovidros via impressão 3D
Beneficiário:Eduardo Henrique Backes
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 21/11538-8 - Bioatividade e ação bactericida de scaffold constiuídos de PLA-TCP modificado com SiO2, ZnO e CeO2 e obtidos por impressão 3D aplicados para engenharia de tecido ósseo
Beneficiário:Samarah Vargas Harb
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
Processo FAPESP: 22/03157-7 - Manufatura aditiva de compósitos bioativos para engenharia de tecidos
Beneficiário:Lidiane Cristina Costa
Modalidade de apoio: Auxílio à Pesquisa - Projeto Inicial