Discovery, Biosynthesis, Total Synthesis, and Biological Activities of Solanapyrones: [4+2] Cycloaddition-Derived Polyketides of Fungal Origin

Autor(es)

Berlinck, Roberto G. S. ; Skellam, Elizabeth

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. N/A, p. 15-pg., 2024-11-15.

Resumo

Solanapyrones are metabolites bearing a 3,4-dehydrodecalin moiety isolated from cultures of different fungi that are associated with plant diseases. Research on solanapyrones resulted in the first report of a Diels-Alderase enzyme implicated in natural product biosynthesis related to the formation of the 3,4-dehydrodecalin core. In addition, several total syntheses of solanapyrones have been reported, which are also connected with the formation of the characteristic cycloaddition-derived 3,4-dehydrodecalin moiety. This Review provides the first comprehensive overview on the chemistry, biosynthesis, and biological activities of solanapyrones under the theme of synthetic and biosynthetic research progress on cycloaddition-derived secondary metabolites. (AU)

• Processo FAPESP: 19/17721-9 - A função da Química na adaptação de holobiontes
• Beneficiário: Roberto Gomes de Souza Berlinck
• Modalidade de apoio: Auxílio à Pesquisa - Temático