Exploring photodynamic inactivation to combat antimicrobial resistance

Autor(es)

Soares, Jennifer M. ; Bagnato, Vanderlei S. ; Branco, Kate C.

• Tipo de documento: Artigo Científico
• Fonte: PHOTONIC DIAGNOSIS, MONITORING, PREVENTION, AND TREATMENT OF INFECTIONS AND INFLAMMATORY DISEASES 2024; v. 12822, p. 5-pg., 2024-01-01.

Resumo

The rise of antimicrobial-resistant microorganisms prompts the exploration of strategies to rejuvenate traditional antibiotics. Photodynamic Inactivation (PDI) offers an alternative by combining a photosensitizer (PS) with light, generating reactive oxygen species that efficiently eliminate undesirable cells. In this study, curcumin and 450 nm light are applied, resulting in reduced minimum inhibitory concentrations (MIC) for antibiotics. The application of PDI proves effective in diminishing the necessary antibiotic dosage for bacterial cell elimination, especially against resistant strains. Additionally, the interaction between the photosensitizer and antibiotics induces notable alterations in bacterial metabolism and biomolecules. These findings are crucial for advancing from in vitro studies to the clinical implementation of PDI as a promising adjunct to antibiotic therapy, offering potential solutions in the battle against antimicrobial resistance. (AU)

• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/50857-8 - INCT 2014 - de Óptica Básica e Aplicada às Ciências da Vida
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Temático