Strontium-loaded titanium surface promotes the MC3T3-E1 pre-osteoblasts growth and S. aureus adhesion

Autor(es)

Cominotte, Mariana Aline ; Santana, Luis Carlos Leal ; de Foggi, Camila Cristina ; Matos, Flavia Gomes ; Florian, Fernanda ; de Assis, Marcelo ; Vergani, Carlos Eduardo ; Vaz, Luis Geraldo ; Longo, Elson ; Cirelli, Joni Augusto

• Tipo de documento: Artigo Científico
• Fonte: Journal of Materials Research; v. 39, n. 8, p. 14-pg., 2024-02-29.

Resumo

Addressing the challenges of biomedical implant failures necessitates innovative approaches within biomaterials research. This study introduces a groundbreaking methodology to enhance both osteogenic and antibacterial properties in biomedical implants focusing on strontium properties. Three titanium surfaces-machine-polished (control), alkaline-etched (AES), and strontium-loaded alkaline-etched (Sr-AES) were evaluated. The results highlight the AES and Sr-AES groups exhibit heightened surface free energy and wettability. Sr+ release peaks on days 1 and 3, tapering off later timepoints. The Sr-AES group demonstrates a trend toward increased MC3T3-E1 proliferation at days 10 and 14. Notwithstanding, the AES and Sr-AES groups presented a greater proportion of viable S. aureus compared to the control. This study unveils Sr-AES as a novel titanium surface modification, showing potential in fostering MC3T3-E1 pre-osteoblast cell growth despite lacking antibiofilm effects. These findings bear significant implications for the progression of biomedical implants, urging sustained innovation in materials design for enhanced biological compatibility. (AU)

• Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Elson Longo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs