Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

Autor(es)

Petry, Romana ; de Almeida, James M. ; Coa, Francine ; de Lima, Felipe Crasto ; Martinez, Diego Stefani T. ; Fazzio, Adalberto

• Tipo de documento: Artigo Científico
• Fonte: BEILSTEIN JOURNAL OF NANOTECHNOLOGY; v. 15, p. 15-pg., 2024-10-30.

Resumo

Graphene oxide (GO) undergoes multiple transformations when introduced to biological and environmental media. GO surface favors the adsorption of biomolecules through different types of interaction mechanisms, modulating the biological effects of the material. In this study, we investigated the interaction of GO with tannic acid (TA) and its consequences for GO toxicity. We focused on understanding how TA interacts with GO, its impact on the material surface chemistry, colloidal stability, as well as, toxicity and biodistribution using the Caenorhabditis elegans model. Employing computational modeling, including reactive classical molecular dynamics and ab initio calculations, we reveal that TA preferentially binds to the most reactive sites on GO surfaces via the oxygen-containing groups or the carbon matrix; van der Waals interaction forces dominate the binding energy. TA exhibits a dose-dependent mitigating effect on the toxicity of GO, which can be attributed not only to the surface interactions between the molecule and the material but also to the inherent biological properties of TA in C. elegans. Our findings contribute to a deeper understanding of GO's environmental behavior and toxicity and highlight the potential of tannic acid for the synthesis and surface functionalization of graphene-based nanomaterials, offering insights into safer nanotechnology development. (AU)

• Processo FAPESP: 18/25103-0 - Interfaces - grafenos funcionalizados e poluentes orgânicos: uma abordagem teórica-experimental em nanotecnologia ambiental
• Beneficiário: Romana Petry
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 17/02317-2 - Interfaces em materiais: propriedades eletrônicas, magnéticas, estruturais e de transporte
• Beneficiário: Adalberto Fazzio
• Modalidade de apoio: Auxílio à Pesquisa - Temático