| Texto completo | |
| Autor(es): Mostrar menos - |
Bergamo, Edmara T. P.
;
Witek, Lukasz
;
Ramalho, Ilana Santos
;
Lopes, Adolfo Coelho de Oliveira
;
Nayak, Vasudev Vivekanand
;
Torroni, Andrea
;
Slavin, Blaire V.
;
Bonfante, Estevam A.
;
Uhrich, Kathryn E.
;
Graves, Dana T.
;
Coelho, Paulo G.
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ACS BIOMATERIALS SCIENCE & ENGINEERING; v. 10, n. 5, p. 11-pg., 2024-04-09. |
| Resumo | |
To develop a peri-implantitis model in a Gottingen minipig and evaluate the effect of local application of salicylic acid poly(anhydride-ester) (SAPAE) on peri-implantitis progression in healthy, metabolic syndrome (MS), and type-2 diabetes mellitus (T2DM) subjects. Eighteen animals were allocated to three groups: (i) control, (ii) MS (diet for obesity induction), and (iii) T2DM (diet plus streptozotocin for T2DM induction). Maxillary and mandible premolars and first molar were extracted. After 3 months of healing, four implants per side were placed in both jaws of each animal. After 2 months, peri-implantitis was induced by plaque formation using silk ligatures. SAPAE polymer was mixed with mineral oil (3.75 mg/mu L) and topically applied biweekly for up to 60 days to halt peri-implantitis progression. Periodontal probing was used to assess pocket depth over time, followed by histomorphologic analysis of harvested samples. The adopted protocol resulted in the onset of peri-implantitis, with healthy minipigs taking twice as long to reach the same level of probing depth relative to MS and T2DM subjects (similar to 3.0 mm), irrespective of jaw. In a qualitative analysis, SAPAE therapy revealed decreased levels of inflammation in the normoglycemic, MS, and T2DM groups. SAPAE application around implants significantly reduced the progression of peri-implantitis after similar to 15 days of therapy, with similar to 30% lower probing depth for all systemic conditions and similar rates of probing depth increase per week between the control and SAPAE groups. MS and T2DM conditions presented a faster progression of the peri-implant pocket depth. SAPAE treatment reduced peri-implantitis progression in healthy, MS, and T2DM groups. (AU) | |
| Processo FAPESP: | 19/08693-1 - Compósitos experimentais à base de alumina e zircônia infiltrados por vidro: caracterização microestrutural e das propriedades ópticas e mecânicas. |
| Beneficiário: | Edmara Tatiely Pedroso Bergamo |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 21/08018-2 - Caracterização nanomecânica de compósitos ZTA e ATZ infiltrados por vidro |
| Beneficiário: | Edmara Tatiely Pedroso Bergamo |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |