Sonification of Deproteinized Bovine Bone Functionalized with Genistein Enhances Bone Repair in Peri-Implant Bone Defects in Ovariectomized Rats

Autor(es)

Duarte, Nathalia Dantas ; Mulinari-Santos, Gabriel ; Batista, Fabio Roberto de Souza ; Gomes, Marcelly Braga ; Monteiro, Naara Gabriela ; da Silva, Ana Claudia Ervolino ; Gruber, Reinhard ; Lisboa-Filho, Paulo Noronha ; Gomes-Ferreira, Pedro Henrique Silva ; Okamoto, Roberta

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF FUNCTIONAL BIOMATERIALS; v. 15, n. 11, p. 12-pg., 2024-11-01.

Resumo

Estrogen deficiency is one of several contributing factors to catabolic changes in bone surrounding dental implants, impairing bone repair in defects requiring bone regeneration. Functionalizing bone substitutes is an alternative approach among various strategies to address this challenge. In this study, the aim was to evaluate the effect of functionalizing deproteinized bovine bone (Bio-Oss (R), BO) with genistein via sonication on peri-implant bone defects in ovariectomized rats. The animals were randomly distributed according to the treatment into the following four groups (n = 10): BO sonicated with genistein (BOS + GEN), BO sonicated alone (BOS), untreated BO (BO), and blood clot only (CLOT). After twenty-eight days, implant removal torque was determined, and the peri-implant bone parameters were calculated based on computed microtomography. Additionally, the gene expression of bone turnover markers was evaluated. As a main result, the functionalization with genistein increased implant removal torque and the peri-implant bone volume in the BOS + GEN group compared to both BOS and BO groups (both p < 0.05). These findings suggest that the sonification of deproteinized bovine bone functionalized with genistein improves bone repair in peri-implant bone defects in ovariectomized rats. (AU)

• Processo FAPESP: 22/07158-8 - Avaliação do reparo ósseo após a utilização de substitutos ósseos funcionalizados por genisteína no preenchimento de defeitos periimplantares: estudo pré-clínico em ratas ovariectomizadas
• Beneficiário: Nathália Dantas Duarte
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 23/05814-8 - Liberação local de Genisteína associada ao Biogran® no preenchimento de defeitos perimplantares: estudo pré-clínico em ratas ovariectomizadas.
• Beneficiário: Marcelly Braga Gomes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica