| Texto completo | |
| Autor(es): |
Kimura, Talita de Carvalho
;
de Lima-Souza, Reydson Alcides
;
Lavareze, Luccas
;
Abu Egal, Erika Said
;
Altemani, Albina
;
Mariano, Fernanda Viviane
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY; v. 126, n. 5, p. 8-pg., 2024-12-17. |
| Resumo | |
Hybrid carcinomas (HC) are the association of two or more malignant neoplasms arising within the same topographical area. The present study is a systematic review of HC of the salivary glands. This study aimed to assess HC clinicopathological features and molecular profile. Observational studies, case series, and case reports were included. PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched until June 2024. A total of 18 articles including 34 patients were included. HC of the salivary glands is presented as a painless mass affecting mainly the parotid gland of adults with a preference for male patients. Histologically, adenoid cystic carcinoma and epithelial-myoepithelial carcinoma were the most prevalent association, being surgical excision with radiotherapy the most common treatment. The most aggressive component, even when representing only a small proportion of the tumor, should guide the patient's treatment. Further molecular studies are necessary to determine if HC are distinct entities or biologically identical to the individual neoplasms. In conclusion, this systematic review may contribute to a better understanding of this rare lesion, their biological behavior, treatments employed, and the outcome of these patients. (c) 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies. (AU) | |
| Processo FAPESP: | 20/08431-4 - Análise do perfil metabolômico na transformação maligna do adenoma pleomórfico |
| Beneficiário: | Reydson Alcides de Lima Souza |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 15/07304-0 - Estudo das alterações genéticas e metabólicas do adenoma pleomorfo e carcinoma ex-adenoma pleomorfo por exoma, expressão gênica e imunohistoquímica |
| Beneficiário: | Fernanda Viviane Mariano Brum Corrêa |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 22/11861-6 - Análise comparativa de exoma de Carcinoma Adenóide Cístico em modelo de xenoenxerto com e sem terapia com entinostat e cisplatina |
| Beneficiário: | Luccas Lavareze dos Reis |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |