VaxGO: an interactive web tool for systems vaccinology data analysis

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Prates-Syed, Wasim Aluisio ; Lima, Aline Aparecida ; Cortes, Nelson ; Carvalho, Evelyn ; Silva, Jaqueline Dinis Queiroz ; Hamaguchi, Barbara ; Duraes-Carvalho, Ricardo ; Cabral-Marques, Otavio ; Hagan, Thomas ; Krieger, Jose E. ; Cabral-Miranda, Gustavo

• Tipo de documento: Artigo Científico
• Fonte: BIOINFORMATICS ADVANCES; v. 5, n. 1, p. 5-pg., 2025-01-01.

Resumo

Motivation RNA sequencing is crucial for investigating transcriptional patterns in immunology and vaccine research. However, the analysis of RNA sequencing data often requires programming skills, which can limit accessibility for researchers lacking such expertise.Results We present VaxGO, an intuitive web-based tool designed to facilitate the analysis of differentially expressed genes in the context of immune processes and cells during vaccination. This tool integrates data from Gene Ontology, CellMarker 2.0, the MSigDB Vax collection, and other key studies, including transcriptional atlases of vaccines against COVID-19 and other diseases. VaxGO is an interactive, web-based tool, offering a user-friendly platform for exploring immune responses and vaccine efficacy without programming expertise.Availability and implementation The VaxGO tool is available at https://github.com/wapsyed/VaxGO. (AU)

• Processo FAPESP: 25/01063-3 - Um estudo de vacinologia de sistemas entre humanos e animais-modelo para medicina translacional
• Beneficiário: Wasim Aluísio Prates Syed
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 19/14526-0 - Desenvolvimento de vacinas contra Streptococcus pyogenes e Chikungunya utilizando VLPs
• Beneficiário: Gustavo Cabral de Miranda
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 21/08468-8 - Desenvolvimento de vacinas baseadas em VLPs contra SARS-CoV-2 e outros Coronavírus humanos
• Beneficiário: Wasim Aluísio Prates Syed
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 20/05146-7 - Desenvolvimento de vacina anti-SARS-CoV-2 utilizando VLPs
• Beneficiário: Gustavo Cabral de Miranda
• Modalidade de apoio: Auxílio à Pesquisa - Regular