Autor(es):Mostrar menos -

Vendramini, Thiago Henrique Annibale ; Marchi, Pedro Henrique ; Olivindo, Rodrigo Fernando Gomes ; Pedrinelli, Vivian ; Amaral, Andressa Rodrigues ; de Miranda, Mariana Santos ; Principe, Leonardo Andrade ; Cesar, Cinthia Goncalves Lenz ; Zafalon, Rafael Vessecchi Amorim ; Perini, Mariana Pamplona ; Lima, Lais Oyama Cotrim ; Balieiro, Julio Cesar de Carvalho ; Brunetto, Marcio Antonio

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION RESEARCH REVIEWS; v. N/A, p. 16-pg., 2025-06-11.

Resumo

This review summarises findings from studies in companion animals with chronic diseases receiving omega-3 supplementation. Investigated conditions included dermatopathies (dogs n = 7), osteoarthritis (dogs n = 7, cats n = 2), cardiovascular diseases (dogs n = 7), dyslipidaemias (dogs n = 1), gastroenteropathies (dogs n = 2), chronic kidney disease (dogs n = 2, cats n = 3), cognitive impairment (dogs n = 4, cats n = 1), and behavioural disorders (dogs n = 3). When possible, dosages were standardised to mg/kg using available data on food intake and EPA/DHA concentrations. The minimum and maximum ranges of EPA and DHA, along with their ratios, were as follows: for dermatology 0<middle dot>99-43 mg/kg EPA and 0<middle dot>66-30 mg/kg DHA (ratio 1<middle dot>4-3<middle dot>4); for osteoarthritis 48-100 mg/kg EPA and 20-32 mg/kg DHA (ratio 1<middle dot>5-3<middle dot>4); cardiology 27-54<middle dot>2 mg/kg EPA and 18-40<middle dot>6 mg/kg DHA (ratio 1<middle dot>3-1<middle dot>5); dyslipidaemia 58<middle dot>8 mg/kg EPA and 45<middle dot>4 mg/kg DHA (ratio 1<middle dot>3); cognition (1/5 studies) 225 mg/kg EPA and 90 mg/kg DHA (ratio 2<middle dot>5); behaviour (1/3) 31 mg/kg EPA and 45 mg/kg DHA (ratio 0<middle dot>7). Nephrology and oncology studies lacked sufficient data for calculation. Gastrointestinal diseases do not appear to benefit from omega-3 supplementation, likely due to inflammation-related malabsorption, although few adverse effects were reported in dogs. Other enteropathy studies were low-quality (case reports/series). The lowest omega-6/omega-3 ratio with anti-inflammatory effect was 1:3<middle dot>75, and the highest was 5<middle dot>5:1. In conclusion, the reviewed EPA and DHA doses appear effective for atopic dermatitis, osteoarthritis, cardiac disease, hyperlipidaemia, and cognitive and behavioural disorders. Further research is needed to clarify efficacy in gastrointestinal and oncological conditions. (AU)

• Processo FAPESP: 23/07307-6 - Análise multi-ômica do metabolismo e microbiota de cães e gatos saudáveis e doentes
• Beneficiário: Thiago Henrique Annibale Vendramini
• Modalidade de apoio: Bolsas no Brasil - Projeto Geração
• Processo FAPESP: 23/07727-5 - Análise multi-ômica do metabolismo e microbioma de cães e gatos saudáveis e doentes renais crônicos
• Beneficiário: Laís Oyama Cotrim Lima
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 23/09486-5 - Efeitos da ingestão de diferentes aditivos em variáveis fermentativas, imunológicas, inflamatórias, metabólicas, saciedade e microbiota fecal de cães obesos
• Beneficiário: Pedro Henrique Marchi
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 22/06499-6 - Análise multi-ômica do metabolismo e microbiota de cães e gatos saudáveis e doentes
• Beneficiário: Thiago Henrique Annibale Vendramini
• Modalidade de apoio: Auxílio à Pesquisa - Projeto Geração