| Texto completo | |
| Autor(es): |
Gabriel, Arthur M.
;
Damian-Buda, Andrada-Ioana
;
Brugnari, Fernanda M.
;
Camargo, Emerson R.
;
Boccaccini, Aldo R.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MATERIALS TODAY BIO; v. 36, p. 23-pg., 2026-02-01. |
| Resumo | |
Core-shell engineered nanoparticles have emerged as multifunctional platforms for biomedical applications by enabling precise spatial control over their structure, controlled release, and interaction with biological tissues. Among the core materials, bioactive glasses offer unique advantages over conventional silica due to their intrinsic bioactivity and the release of therapeutic ions. This review provides a comprehensive analysis of coreshell nanostructures that use bioactive glass as the core, and shells composed of a wide range of inorganic and polymeric materials, engineered to control their release capabilities and biological performance. The composition and synthesis strategies of bioactive glass nanoparticles are discussed. The types of shell materials are also evaluated, highlighting their physicochemical roles in modulating drug diffusion, stability, degradation, and biological targeting. Inorganic, natural, and synthetic polymeric shells are discussed, focusing on how they can be used to tailor the properties of the nanoparticles. Key challenges related to in vivo performance assays, immunological responses, degradation behavior, and translational barriers, outlining future directions for clinical implementation, are also explored. By integrating the structural functionalities of bioactive glasses with advanced surface engineering, the core-shell structures discussed in this review represent a versatile, highly tunable and customizable strategy for next-generation biomedical therapies. (AU) | |
| Processo FAPESP: | 24/00989-7 - Centro de Pesquisa em Engenharia Molecular para Materiais Avançados (CEMol) |
| Beneficiário: | Edson Roberto Leite |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 22/10016-0 - Nanocompósitos termossensíveis para transporte e liberação controlada de medicamentos |
| Beneficiário: | Arthur Martins Gabriel |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 24/13967-1 - Desenvolvimento de nanocompositos termossensíveis de PNVCL e vidrobioativo para regereração de tecido ósseo |
| Beneficiário: | Arthur Martins Gabriel |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto |
| Processo FAPESP: | 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais |
| Beneficiário: | Elson Longo da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |