| Texto completo | |
| Autor(es): |
Queiroz, Luiz Adriano Damasceno
;
Barros, Rafael Santos
;
Assis, Josiane Betim
;
Silva, Camille Cristine Caldeira
;
Turato, Walter Miguel
;
Bustia, Sofia Xavier
;
Rodrigues, Stephen Fernandes
;
Sa-Nunes, Anderson
;
Martins, Joilson O.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN IMMUNOLOGY; v. 16, p. 15-pg., 2025-10-21. |
| Resumo | |
Aging involves a gradual decline in physiological integrity, and rapamycin (RAPA) has demonstrated potential as an anti-aging agent. Nonetheless, its effects on glucose metabolism and immune function may vary based on dosage and administration regimen. This study investigates the impact of intermittent low-dose RAPA on glucose metabolism and immune function in Senescence-Accelerated Mouse Prone 8 (SAMP8) and Senescence-Accelerated Mouse Resistant 1 (SAMR1) mice. Twelve-week-old male SAMP8 and SAMR1 mice were treated with RAPA (0.78 mu g/kg) every five days for six months. Glucose uptake, mitochondrial respiratory capacity, spleen and thymus immunophenotype, lymphoproliferation, and cytokine profiles were evaluated. Our findings indicate that RAPA reduced glucose uptake in the bladder and the percentage of FoxP3+ lymphocytes in the spleen of SAMP8 mice, while enhancing mitochondrial respiratory control and ATP production in liver. In SAMR1 mice, RAPA administration led to a decrease in CD3+ thymocytes and splenic lymphoproliferative capacity, while also enhanced mitochondrial performance. Comparisons between Control groups revealed that SAMP8 mice exhibited higher glucose uptake in several tissues, lower lymphocyte populations in spleen and thymus, altered CD4+/CD8+ ratios, and reduced IL-4 expression compared with SAMR1 mice. The findings reinforce the potential of RAPA to modulate aging-related processes, highlighting improvements in mitochondrial function and energy metabolism across strains with different aging processes. However, the immunosuppressive effects of RAPA remain evident, even at low doses administered intermittently, in an age- and strain-specific manner. These findings emphasize the therapeutic potential of RAPA while underscoring the need for customized dosing strategies to balance efficacy and safety. These data highlight mitochondrial metabolic improvements as the primary benefit of intermittent low-dose RAPA and suggest potential clinical relevance for conditions involving compromised mitochondrial energy metabolism. (AU) | |
| Processo FAPESP: | 24/00810-7 - Investigando mecanismos autofágicos na vigência de micose subcutânea causada por Sporotrhix brasiliensis em animais diabéticos |
| Beneficiário: | Joilson de Oliveira Martins |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/05439-4 - Regulação do receptor mTOR por rapamicina em camundongos de senescência acelerada: o papel da autofagia no processo de envelhecimento |
| Beneficiário: | Luiz Adriano Damasceno de Queiroz |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 23/05115-2 - Efeito do tratamento com AP39 ou ATB346, doadores de H2S mitocondrial e híbrido, respectivamente, em modelo experimental de trombose: Ensaios in vivo em vasos sanguíneos cerebrais e in vitro |
| Beneficiário: | Stephen Fernandes de Paula Rodrigues |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 22/02742-3 - Caracterização molecular, bioquímica e imunológica de inibidores de proteases salivares de Amblyomma sculptum: do desenvolvimento de imunobiológicos a estratégias anti-carrapato |
| Beneficiário: | Anderson de Sá Nunes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 22/00482-4 - Investigando mecanismos autofágicos em camundongos com senescência acelerada |
| Beneficiário: | Joilson de Oliveira Martins |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |