Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases

Autor(es)

de Godoy, Andre Schutzer ^[1] ; Fernandes, Rafaela Sachetto ^[1] ; Campos Aguiar, Anna Caroline ^[1] ; Bueno, Renata Vieira ^[1] ; de Moraes Roso Mesquita, Nathalya Cristina ^[1] ; Carvalho Guido, Rafael Victorio ^[1] ; Oliva, Glaucius ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Phys Sao Carlos, Ave Joao Dagnone 1100, BR-13563120 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CURRENT OPINION IN STRUCTURAL BIOLOGY; v. 59, p. 65-72, DEC 2019.
• Citações Web of Science: 0

Resumo

With almost half of the world population living at risk, tropical infectious diseases cause millions of deaths every year in developing countries. Considering the lack of economic prospects for investment in this field, approaches aiming the rational design of compounds, such as structure-based drug discovery (SBDD), fragment screening, target-based drug discovery, and drug repurposing are of special interest. Herein, we focused in the advances on the field of SBDD targeting arboviruses such as dengue, yellow fever, zika and chikungunya enzymes of the RNA replication complex (RC) and enzymes involved in a variety of pathways essential to ensure parasitic survival in the host, for malaria, Chagas e leishmaniasis diseases. We also highlighted successful examples such as promising new inhibitors and molecules already in preclinical/clinical phase tests, major gaps in the field and perspectives for the future of drug design for tropical diseases. (AU)

• Processo FAPESP: 16/19712-9 - Caracterização estrutural das proteínas do vírus Zika e busca por agentes antivirais
• Beneficiário: Andre Schutzer de Godoy
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/05130-3 - Construção e caracterização de um sistema replicon sub-genômico do ZIKV para a descoberta de agentes antivirais.
• Beneficiário: Rafaela Sachetto Fernandes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 15/18192-9 - Descoberta e Desenvolvimento de Fármacos Antimaláricos: Biologia Estrutural, Química Medicinal e Parasitologia
• Beneficiário: Anna Caroline Campos Aguiar
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado