Alpha2-adrenoceptor and adenosine A1 receptor within the nucleus tractus solitarii in hypertension development

Autor(es)

Santiago, Fernando E. ^[1] ; Fior-Chadi, Debora R. ^[2] ; Carrettiero, Daniel C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210170 Santo Andre, SP - Brazil

^[2] Univ Sao Paulo, Dept Fisiol, Inst Biociencias, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 187, p. 36-44, JAN 2015.
• Citações Web of Science: 3

Resumo

Alpha2-adrenoceptor and A1 adenosine receptor systems within the nucleus tractus solitarii (NTS) play an important role in cardiovascular control. Deregulation of these systems may result in an elevated sympathetic tone, one of the root causes of neurogenic hypertension. The dorsomedial/dorsolateral and subpostremal NTS subnuclei of spontaneously hypertensive rats (SHR) show density changes in both receptors, even at 15 days of age, prior to the onset of hypertension. In addition, adenosine A1 receptors have been specifically reported to modulate alpha2-adrenoceptors in several brain regions, including the NTS, via a PLC-dependent pathway involving cross regulation between sympathetic neurons and astrocytes. The physiological cross talk between these receptor systems is also deregulated in SHR suggesting that alpha2-adrenoceptor and A1 adenosine receptor might be germane to the development of hypertension. In this review, we will focus on these systems within the NTS during development, pointing out some interesting modulations in processes, and chemical changes within specific subnuclei of NTS circuitry, that might have implications for neurogenic hypertension. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 10/19849-8 - Estudo dos mecanismos envolvidos na liberação de neurotransmissores: análise utilizando o modelo de ativação do receptor A2a de adenosina
• Beneficiário: Debora Rejane Fior Chadi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/11446-4 - Um estudo sobre a relação dos receptores nicotínicos com a degradação de isoformas tóxicas de Tau na Doença de Alzheimer: envolvimento da co-chaperona BAG2?
• Beneficiário: Daniel Carneiro Carrettiero
• Modalidade de apoio: Auxílio à Pesquisa - Regular