The effect of simvastatin treatment on bone repair of femoral fracture in animal model

Autor(es)

Mardegan Issa, Joao Paulo ^[1] ; de Lucia, Conrado Ingraci ^[1] ; dos Santos Kotake, Bruna Gabriela ^[1] ; Gonzaga, Miliane Goncalves ^[1] ; Tocchini de Figueiredo, Fellipe Augusto ^[1] ; Iyomasa, Daniela Mizusaki ^[1] ; Macedo, Ana Paula ^[1] ; Ervolino, Edilson ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, BR-14040904 Sao Paulo - Brazil

^[2] Paulista State Univ Aracatuba, Sch Dent Aracatuba, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GROWTH FACTORS; v. 33, n. 2, p. 139-148, APR 2015.
• Citações Web of Science: 9

Resumo

The aim of this research was to evaluate the fracture healing area in osteoporotic femur of female rats restrained by stainless steel wire by statin administration in two different doses (5 mg and 20 mg). Ninety female rats were divided into six groups (n = 15): SH, SH-5 mg, SH-20 mg, OVX, OVX-5 mg, and OVX-20 mg. The surgery consisted of the fracture of the left femur bone and stabilization by K-wire and the administration was restricted and weekly controlled in the drinking water. The euthanasia was conducted at three different moments, five animals per period: 7 d, 14 d, and 28 d. Densitometry, zymography, and histological analyses showed a significant difference between some groups. According to these findings, simvastatin promoted a positive action for bone repair, especially in the osteometabolic group treated with 20 mg of the drug. (AU)

• Processo FAPESP: 11/13449-0 - Efeito do tratamento com sinvastatina no reparo ósseo de fratura femural em modelo animal de osteoporose
• Beneficiário: João Paulo Mardegan Issa
• Modalidade de apoio: Auxílio à Pesquisa - Regular