Biocompatible xanthan/polypyrrole scaffolds for tissue engineering

Autor(es)

Bueno, Vania Blasques ^[1] ; Takahashi, Suelen Harumi ^[1] ; Catalani, Luiz Henrique ^[1] ; Cordoba de Torresi, Susana Ines ^[1] ; Siqueira Petri, Denise Freitas ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, BR-05513970 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 52, p. 121-128, JUL 1 2015.
• Citações Web of Science: 15

Resumo

Polypyrrole (PPy) was electropolymerized in xanthan hydrogels (XCA), resulting in electroactive XCAPPy scaffolds with (15 +/- 3) wt.% PPy and (40 +/- 10) pm thick. The physicochemical characterization of hybrid XCAPPy scaffolds was performed by means of cyclic voltammetry, swelling tests, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analyses (TGA), scanning electron microscopy (SEM), atomic force microscopy (AFM) and tensile tests. XCAPPy swelled similar to 80% less than XCA. FIR spectra and thermal analyses did not evidence strong interaction between PPy and XCA matrix. XCAPPy presented a porous stratified structure resulting from the arrangement of PPy chains parallel to XCA surface. Under stress XCAPPy presented larger strain than neat XCA probably due to the sliding of planar PPy chains. The adhesion and proliferation of fibroblasts onto XCA and XCAPPy were evaluated in the absence and in the presence of external magnetic field (EMF) of 0.4 T, after one day, 7 days, 14 days and 21 days. Fibroblast proliferation was more pronounced onto XCAPPy than onto XCA, due to its higher hydrophobicity and surface roughness. EMF stimulated cell proliferation onto both scaffolds. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 10/13034-2 - Produção de suportes biodegradáveis de hidrogel de polissacarídeos para crescimento celular
• Beneficiário: Vânia Aparecida Blasques Bueno Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado