Design and characterization of chitosan/zeolite composite films - Effect of zeolite type and zeolite dose on the film properties

Autor(es)

Barbosa, Gustavo P. ^[1] ; Debone, Henrique S. ^[1] ; Severino, Patricia ^[2] ; Souto, Eliana B. ^{[3, 4, 5]} ; da Silva, Classius F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Rua Sao Nicolau 210, BR-09913030 Diadema - Brazil

^[2] Univ Tiradentes, Inst Tecnol & Pesquisa, Aracaju - Brazil

^[3] Univ Coimbra FFUC, Fac Pharm, Dept Pharmaceut Technol, Polo Ciencias Saude, P-3000548 Coimbra - Portugal

^[4] Univ Coimbra, Polo Ciencias Saude, Ctr Neurosci & Cell Biol, P-3000548 Coimbra - Portugal

^[5] Univ Coimbra, Polo Ciencias Saude, Inst Biomed Imaging & Life Sci CNC IBILI, P-3000548 Coimbra - Portugal

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 60, p. 246-254, MAR 1 2016.
• Citações Web of Science: 16

Resumo

Chitosan films can be used as wound dressings for the treatment of chronic wounds and severe burns. The antimicrobial properties of these films may be enhanced by the addition of silver. Despite the antimicrobial activity of silver, several studies have reported the cytotoxicity as a factor limiting its biomedical applications. This problem may, however, be circumvented by the provision of sustained release of silver. Silver zeolites can be used as drug delivery platforms to extend the release of silver. The objective of this study was to evaluate the addition of clinoptilolite and A-type zeolites in chitosan films. Sodium zeolites were initially subjected to ion-exchange in a batch reactor. Films were prepared by casting technique using a 2% w/w chitosan solution and two zeolite doses (0.1 or 0.2% w/w). Films were characterized by thermal analysis, color analysis, scanning electron microscopy, X-ray diffraction, and water vapor permeation. The results showed that films present potential for application as dressing. The water vapor permeability is one of the main properties in wound dressings, the best results were obtained for A-type zeolite/chitosan films, which presented a brief reduction of this property in relation to zeolite-free chitosan film. On the other hand, the films containing clinoptilolite showed lower water vapor permeation, which may be also explained by the best distribution of the particles into the polymer which also promoted greater thermal resistance. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 10/17721-4 - Filmes de quitosana contendo fitoterápicos para aplicação como curativos cicatrizantes
• Beneficiário: Classius Ferreira da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular