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Tribl, Gotthard G.
[1, 2]
;
Trindade, Mateus C.
[1]
;
Bittencourt, Thais
[2]
;
Lorenzi-Filho, Geraldo
[2]
;
Alves, Rosana Cardoso
[1]
;
de Andrade, Daniel Ciampi
[1]
;
Fonoff, Erich T.
[1]
;
Bor-Seng-Shu, Edson
[1]
;
Machado, Alexandre A.
[1]
;
Schenck, Carlos H.
[3, 4]
;
Teixeira, Manoel J.
[1]
;
Barbosa, Egberto R.
[1]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Med, Hosp Clin, Div Neurol & Neurosurg, Ave Dr Eneas Carvalho Aguiar, 255, 5 Andar, BR-05403900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, InCor, Sleep Lab, Pulm Div, Ave Dr Eneas Carvalho Aguiar, 44, Cerqueira Cesar, BR-05403000 Sao Paulo - Brazil
[3] Hennepin Cty Med Ctr, Minnesota Reg Sleep Disorders Ctr, Dept Psychiat, 701 Pk Ave, Minneapolis, MN 55415 - USA
[4] Univ Minnesota, Sch Med, 701 Pk Ave, Minneapolis, MN 55415 - USA
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Sleep Medicine; v. 17, p. 179-185, JAN 2016. |
| Citações Web of Science: | 10 |
| Resumo | |
Objective: Quantitative data are reported on rapid eye movement (REM) sleep behavior disorder (RBD) in a cohort of predominantly neurological Wilson's disease (WD). Methods: A total of 41 patients with WD and 41 healthy, age-and gender-matched controls were studied by conducting face-to-face interviews, neurological and clinical examinations, laboratory tests, and WD and RBD-specific scales. Video-polysomnography and quantification of REM sleep without atonia (RWA) were conducted in 35 patients and 41 controls. Results: Patients with WD showed significantly worse sleep quality, less sleep efficiency, increased wakefulness after sleep onset, and more arousals compared to healthy controls. Five patients with WD (four women) fulfilled the diagnostic criteria for RBD with significantly higher values in RWA, RBD Questionnaire Hong Kong, and RBD Screening Questionnaire compared to patients with WD without RBD. In three patients with WD, RBD had manifested before any other symptom that could be attributed to WD. Percentage of RWA was significantly lower in WD without RBD than in WD with RBD, but still significantly increased compared to controls. Conclusions: RBD can be comorbid with WD. RWA is commonly present in WD, both in the presence or absence of clinical RBD. A causal connection is possible, though retrospective determination of RBD onset and the low number of patients do not allow a definitive conclusion at this point. However, screening for WD in idiopathic RBD is available at low cost and is recommended. Early-stage copper chelation therapy provides a highly effective treatment to prevent further WD manifestations and might also control the comorbid RBD. (C) 2015 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 12/05403-3 - Síndrome das pernas inquietas e Transtorno comportamental do sono REM na doença de Wilson: Prevalência e características clínicas em amostra de um centro de saúde quaternário |
| Beneficiário: | Egberto Reis Barbosa |
| Modalidade de apoio: | Auxílio à Pesquisa - Pesquisador Visitante - Internacional |