Cellular Proliferation Index between Carcinoma Ex-Pleomorphic Adenoma and Pleomorphic Adenoma

Autor(es)

Fernanda Viviane Mariano ^[1] ; Ana Flávia Costa ^[2] ; Rogério Oliveira Gondak ^[3] ; Antonio Santos Martins ^[4] ; André Del Negro ^[5] ; Álfio José Tincani ^[6] ; Albina Altemani ^[7] ; Oslei Paes de Almeida ^[8] ; Luiz Paulo Kowalski ^[9]

Afiliação do(s) autor(es)

^[1] Universidade de Campinas. Department of Pathology, School of Medical Sciences - Brasil

^[2] Hospital AC Camargo. Department of Head and Neck and Otorhinolaryngology - Brasil

^[3] Universidade Federal de Santa Catarina. Department of Pathology - Brasil

^[4] Universidade de Campinas. School of Medical Sciences. Department of Head and Neck - Brasil

^[5] Universidade de Campinas. School of Medical Sciences. Department of Head and Neck - Brasil

^[6] Universidade de Campinas. School of Medical Sciences. Department of Head and Neck - Brasil

^[7] Universidade de Campinas. Department of Pathology, School of Medical Sciences - Brasil

^[8] Universidade de Campinas. Piracicaba Dental School. Department of Oral Pathology - Brasil

^[9] Hospital AC Camargo. Department of Head and Neck and Otorhinolaryngology - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Dental Journal; v. 26, n. 4, p. 416-421, 2015-08-00.

Resumo

<p>Carcinoma ex pleomorphic adenoma (CXPA) has been considered an interesting model of carcinogenesis, presenting various histological subtypes and invasiveness phase. The objective was to determine the proliferative index of CXPA and comparing to pleomorphic adenoma (PA). Thirty six cases of CXPA (36 PA) and 22 areas of PA in CXPA (residual PA) were studied by Ki-67 expression. All CXPA cases were classified according to invasiveness phase (intracapsular, minimally and frankly invasive) and histopathological subtypes. Data was statistically analyzed by Wilcoxon, Mann-Whitney and Kruskal-Wallis tests. CXPA included 5 intracapsular, 9 minimally invasive and 22 frankly invasive cases. Fifteen cases corresponded to salivary duct carcinoma, 7 to adenocarcinoma NOS, 7 myoepithelial, 5 epithelial-myoepithelial, one case of squamous cell and one case of sarcomatoid carcinoma. The Ki-67 index of PA and residual PA were significantly lower than CXPA. Intracapsular and minimally invasive showed smaller proliferative index than frankly invasive. Considering the subtypes of CXPA, there was not a statistic difference among them. Ki-67 is a useful marker in the differential diagnosis of PA and CXPA, even when in the early invasive phase.</p> (AU)

• Processo FAPESP: 11/23204-5 - Estudo do perfil genômico do carcinoma ex-adenoma pleomorfo por hibridização genômica comparativa em microarranjo (CGH array)
• Beneficiário: Albina Messias de Almeida Milani Altemani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/23366-5 - Estudo do perfil genômico do carcinoma ex-adenoma pleomorfo por hibridização genômica comparativa em microarranjo (CGH array)
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado