Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis

Autor(es)

Cosci, Alessandro ; Nogueira, Marcelo Saito ; Pratavieira, Sebastiao ; Takahama, Jr., Ademar ; Azevedo, Rebeca de Souza ; Kurachi, Cristina

• Tipo de documento: Artigo Científico
• Fonte: BIOMEDICAL OPTICS EXPRESS; v. 7, n. 10, p. 4210-4219, OCT 1 2016.
• Citações Web of Science: 14

Resumo

Actinic cheilitis is a potentially malignant disorder of the lips. Its first cause is believed to be UV sun radiation. The lesion is highly heterogeneous, making the choice of area to be biopsied difficult. This study exploits the capabilities of time-resolved fluorescence spectroscopy for the identification of the most representative area to be biopsied. A preliminary study was performed on fourteen patients. A classification algorithm was used on data acquired on nine different biopsies. The algorithm discriminated between absent, mild, and moderate dysplasia with a sensitivity of 92.9%, 90.0%, and 80.0%, respectively. The false positive rate for healthy tissue (specificity) was 88.8%. (C) 2016 Optical Society of America (AU)

• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/16154-0 - Espectroscopia de fluorescência para diagnóstico de lesões de pele clinicamente semelhantes
• Beneficiário: Marcelo Saito Nogueira
• Modalidade de apoio: Bolsas no Brasil - Mestrado