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DECREASED NEURON LOSS AND MEMORY DYSFUNCTION IN PILOCARPINE-TREATED RATS PRE-EXPOSED TO HYPOXIA

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Autor(es):
Do Val-Da Silva, Raquel Araujo ; Peixoto-Santos, Jose Eduardo ; Scandiuzzi, Renata Caldo ; Balista, Priscila Alves ; Bassi, Mirian ; Glass, Mogens Lesner ; Romcy-Pereira, Rodrigo Neves ; Galvis-Alonsa, Orfa Yineth ; Leitea, Joao Pereira
Número total de Autores: 9
Tipo de documento: Artigo Científico
Fonte: Neuroscience; v. 332, p. 88-100, SEP 22 2016.
Citações Web of Science: 3
Resumo

Preconditioning can induce a cascade of cellular events leading to neuroprotection against subsequent brain insults. In this study, we investigated the chronic effects of hypoxic preconditioning on spontaneous recurrent seizures (SRS), neuronal death, and spatial memory performance in rats subjected to pilocarpine (Pilo)-induced status epilepticus (SE). Rats underwent a short hypoxic episode (7% O-2 + 93% N-2; 30 min on two consecutive days) preceding a 4-h SE (HSE group). Control groups were rats submitted to SE only (SE), rats subjected to hypoxia only (H) or normoxia-saline (C). Animals were monitored for the occurrence of SRS, and spatial memory performance was evaluated in the radial-arm maze. Hippocampal sections were analyzed for cell death and mossy fiber sprouting at 1 or 60 days after SE. Compared to SE group, HSE had increased SE latency, reduced number of rats with SRS, reduced mossy fiber sprouting at 60 days, and reduced cell death in the hilus and the CA3 region 1 and 60 days after SE. Additionally, HSE rats had better spatial memory performance than SE rats. Our findings indicated that short hypoxic preconditioning preceding SE promotes long-lasting protective effects on neuron survival and spatial memory. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 10/51515-2 - Estudo das relações entre populações celulares, expressão de aquaporina-4 e sulfato de condroitina com o tempo de relaxamento e taxa de transferência de magnetização no hipocampo de pacientes com..
Beneficiário:José Eduardo Peixoto Santos
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 05/56447-7 - Pesquisa através de imagens por ressonância magnética de alto campo destinadas a estudos em humanos
Beneficiário:João Pereira Leite
Linha de fomento: Auxílio à Pesquisa - Programa CINAPCE - Temático