Therapeutic agents and biocides for ocular infections by free-living amoebae of Acanthamoeba genus

Autor(es)

Carrijo-Carvalho, Linda Christian ; Sant'ana, Viviane Peracini ; Foronda, Annette Silva ; de Freitas, Denise ; de Souza Carvalho, Fabio Ramos

• Tipo de documento: Artigo de Revisão
• Fonte: SURVEY OF OPHTHALMOLOGY; v. 62, n. 2, p. 203-218, MAR-APR 2017.
• Citações Web of Science: 10

Resumo

Acanthamoeba keratitis is a sight-threatening infectious disease. Resistance of the cystic form of the protozoan to biocides and the potential toxicity of chemical compounds to corneal cells are the main concerns related to long-term treatment with the clinically available ophthalmic drugs. Currently, a limited number of recognized antimicrobial agents are available to treat ocular amoebic infections. Topical application of biguanide and diamidine antiseptic solutions is the first-line therapy. We consider the current challenges when treating Acanthamoeba keratitis and review the chemical properties, toxicities, and mechanisms of action of the available biocides. Antimicrobial therapy using anti-inflammatory drugs is controversial, and aspects related to this topic are discussed. Finally, we offer our perspective on potential improvement of the effectiveness and safety of therapeutic profiles, with the focus on the quality of life and the advancement of individualized medicine. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 08/53969-0 - Caracterização genotípica de amebas de vida livre do gênero Acanthamoeba e aplicação no diagnóstico molecular de infecções oculares humanas
• Beneficiário: Denise de Freitas
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/51626-1 - Toxinas de Acanthamoeba spp. como fatores de virulência em infecções da superfície ocular
• Beneficiário: Fábio Ramos de Souza Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores