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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Structural aspects of graphitic carbon modified SBA-15 mesoporous silica and biological interactions with red blood cells and plasma proteins

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Autor(es):
Martinez, Diego S. T. ; Damasceno, Joao Paulo V. ; Franqui, Lidiane S. ; Bettini, Jefferson ; Mazali, Italo O. ; Strauss, Mathias
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 78, p. 141-150, SEP 1 2017.
Citações Web of Science: 3
Resumo

Functional mesoporous materials have been worldwide studied for different applications. Mesoporous silicas are highlighted due to the synthetic possibilities for the preparation of such materials with different particle sizes and morphologies, and controlled pores sizes and structures. Moreover, the silica superficial silanol groups are explored in several chemical modifications, leading to functional materials with tuned functionalities and properties. In this work, an organo-functionalization and pyrolysis synthetic procedure is used to obtain graphitic carbon modified mesoporous SBA-15 silica. The carbon content was tuned during the functionalization step, and the graphitic nanodomains were formed in the pores surface and particles outer surface. Textural and small angle X-ray diffraction analysis accessed the presence of the carbon nanostructures inside the SBA-15 mesopores. Advanced microanalysis using electron energy loss spectroscopy coupled to a transmission electron microscope had confirmed the carbon distribution along the silica pores, which gives higher hydrophobicity and changed the interaction of the mesoporous material with biological systems. Finally, the influence of the surface modification with graphitic carbon species over the interaction with human red blood cells (hemolysis) and human blood plasma (protein corona formation) was elucidated for the very first time for this kind of functional materials. It was observed that the graphitic carbon species considerably reduced the hemolytic effect of the silica particles, and was responsible for modulating the loading and composition of the hard corona plasma proteins. This work deepness the fundamental knowledge on the interaction between such nanomaterials and biological systems, one step further the use of these modified silicas in biomedical applications. (C) 2017 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 13/24400-8 - Sílicas mesoporosas híbridas como plataformas para a obtenção controlada de nanopartículas metálicas: relação entre a nanoestruturação e a atividade catalítica.
Beneficiário:João Paulo Vita Damasceno
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 12/20511-7 - Sistemas químicos integrados baseados em nanoestruturas de carbono suportadas em matrizes porosas: Correlações entre o protocolo de síntese, propriedades físico-químicas e aplicação em cromatografia e eletroquímica.
Beneficiário:Mathias Strauss
Linha de fomento: Bolsas no Brasil - Pós-Doutorado